FEKAP | CAS#2324155-84-0 | biochemical

MedKoo Cat#: 145661 | Name: FEKAP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FEKAP is a novel compound is designed, synthesized, and assayed for in vitro binding affinities. FEKAP displays high KOR binding affinity.

Chemical Structure

FEKAP

CAS#2324155-84-0

Theoretical Analysis

MedKoo Cat#: 145661

Name: FEKAP

CAS#: 2324155-84-0

Chemical Formula: C19H26Cl2FN3O3

Exact Mass: 433.1300

Molecular Weight: 434.33

Elemental Analysis: C, 52.54; H, 6.03; Cl, 16.32; F, 4.37; N, 9.67; O, 11.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

FEKAP;

IUPAC/Chemical Name

methyl (R)-4-(2-(3,4-dichlorophenyl)acetyl)-3-((ethyl(2-fluoroethyl)amino)methyl)piperazine-1-carboxylate

InChi Key

HYCNKKWUFLJJNW-OAHLLOKOSA-N

InChi Code

1S/C19H26Cl2FN3O3/c1-3-23(7-6-22)12-15-13-24(19(27)28-2)8-9-25(15)18(26)11-14-4-5-16(20)17(21)10-14/h4-5,10,15H,3,6-9,11-13H2,1-2H3/t15-/m1/s1

SMILES Code

CCN(CCF)C[C@@H]1CN(CCN1C(=O)CC2=CC(Cl)=C(Cl)C=C2)C(=O)OC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Naganawa M, Li S, Nabulsi N, Lin SF, Labaree D, Ropchan J, Gao H, Mei M, Henry S, Matuskey D, Carson RE, Huang Y. Kinetic Modeling and Test-Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans. J Nucl Med. 2020 Nov;61(11):1636-1642. doi: 10.2967/jnumed.119.227694. Epub 2020 Mar 13. PMID: 32169917; PMCID: PMC9364890. 2: Li S, Zheng MQ, Naganawa M, Gao H, Pracitto R, Shirali A, Lin SF, Teng JK, Ropchan J, Huang Y. Novel Kappa Opioid Receptor Agonist as Improved PET Radiotracer: Development and in Vivo Evaluation. Mol Pharm. 2019 Apr 1;16(4):1523-1531. doi: 10.1021/acs.molpharmaceut.8b01209. Epub 2019 Feb 28. PMID: 30726092. 3: Placzek MS. Imaging Kappa Opioid Receptors in the Living Brain with Positron Emission Tomography. Handb Exp Pharmacol. 2022;271:547-577. doi: 10.1007/164_2021_498. PMID: 34363128.