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MedKoo Cat#: 597324 | Name: Homocarnosine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Homocarnosine is an endogenous dipeptide distributed in cerebral regions and cerebrospinal fluid.

Chemical Structure

Homocarnosine
Homocarnosine
CAS#3650-73-5

Theoretical Analysis

MedKoo Cat#: 597324

Name: Homocarnosine

CAS#: 3650-73-5

Chemical Formula: C10H16N4O3

Exact Mass: 240.1222

Molecular Weight: 240.26

Elemental Analysis: C, 49.99; H, 6.71; N, 23.32; O, 19.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Homocarnosine; L-Homocarnosine; NSC 92522; NSC-92522; NSC92522;
IUPAC/Chemical Name
(4-aminobutanoyl)-L-histidine
InChi Key
CCLQKVKJOGVQLU-QMMMGPOBSA-N
InChi Code
InChI=1S/C10H16N4O3/c11-3-1-2-9(15)14-8(10(16)17)4-7-5-12-6-13-7/h5-6,8H,1-4,11H2,(H,12,13)(H,14,15)(H,16,17)/t8-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CNC=N1)NC(CCCN)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 240.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B(6)-Dependent Epilepsy. Am J Hum Genet. 2016 Dec 1;99(6):1325-1337. doi: 10.1016/j.ajhg.2016.10.011. PubMed PMID: 27912044; PubMed Central PMCID: PMC5142116. 11: Wang X, Fang C, He J, Dai Q, Fang R. Comparison of the meat metabolite composition of Linwu and Pekin ducks using 600 MHz 1H nuclear magnetic resonance spectroscopy. Poult Sci. 2017 Jan 1;96(1):192-199. Epub 2016 Sep 8. PubMed PMID: 27608660. 12: Vistoli G, Colzani M, Mazzolari A, Maddis DD, Grazioso G, Pedretti A, Carini M, Aldini G. Computational approaches in the rational design of improved carbonyl quenchers: focus on histidine containing dipeptides. Future Med Chem. 2016 Sep;8(14):1721-37. doi: 10.4155/fmc-2016-0088. Epub 2016 Sep 1. PubMed PMID: 27584013. 13: Pavlin M, Rossetti G, De Vivo M, Carloni P. Carnosine and Homocarnosine Degradation Mechanisms by the Human Carnosinase Enzyme CN1: Insights from Multiscale Simulations. Biochemistry. 2016 May 17;55(19):2772-84. doi: 10.1021/acs.biochem.5b01263. Epub 2016 May 4. PubMed PMID: 27105448. 14: Lieblein-Boff JC, Johnson EJ, Kennedy AD, Lai CS, Kuchan MJ. Exploratory Metabolomic Analyses Reveal Compounds Correlated with Lutein Concentration in Frontal Cortex, Hippocampus, and Occipital Cortex of Human Infant Brain. PLoS One. 2015 Aug 28;10(8):e0136904. doi: 10.1371/journal.pone.0136904. eCollection 2015. PubMed PMID: 26317757; PubMed Central PMCID: PMC4552625. 15: Solis MY, Cooper S, Hobson RM, Artioli GG, Otaduy MC, Roschel H, Robertson J, Martin D, S Painelli V, Harris RC, Gualano B, Sale C. Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. PLoS One. 2015 Apr 14;10(4):e0123857. doi: 10.1371/journal.pone.0123857. eCollection 2015. PubMed PMID: 25875297; PubMed Central PMCID: PMC4397072. 16: Zhou L, Li H, Hao F, Li N, Liu X, Wang G, Wang Y, Tang H. Developmental Changes for the Hemolymph Metabolome of Silkworm (Bombyx mori L.). J Proteome Res. 2015 May 1;14(5):2331-47. doi: 10.1021/acs.jproteome.5b00159. Epub 2015 Apr 17. PubMed PMID: 25825269; PubMed Central PMCID: PMC4576358. 17: Babizhayev MA. Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechnology for Treating Cognitive Deficits, Depression and Intellectual Disabilities. Curr Pharm Biotechnol. 2014;15(8):738-78. Review. PubMed PMID: 25158972. 18: Veiga-da-Cunha M, Chevalier N, Stroobant V, Vertommen D, Van Schaftingen E. Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase. J Biol Chem. 2014 Jul 11;289(28):19726-36. doi: 10.1074/jbc.M114.576579. Epub 2014 Jun 2. 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