Ranaconitine | CAS#1360-76-5 | alkaloid

MedKoo Cat#: 461152 | Name: Ranaconitine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai.

Chemical Structure

Ranaconitine

CAS#1360-76-5

Theoretical Analysis

MedKoo Cat#: 461152

Name: Ranaconitine

CAS#: 1360-76-5

Chemical Formula: C32H44N2O9

Exact Mass: 600.3047

Molecular Weight: 600.70

Elemental Analysis: C, 63.98; H, 7.38; N, 4.66; O, 23.97

Price and Availability

Size	Price	Availability
1mg	USD 230.00	2 Weeks
5mg	USD 510.00	2 Weeks
10mg	USD 790.00	2 Weeks
25mg	USD 1,210.00	2 Weeks

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Related CAS #

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Synonym

Ranaconitine;

IUPAC/Chemical Name

(3S,6S,7S,7aS,8S,9R,10S,11aS,14S)-1-ethyl-7a,11a,12-trihydroxy-6,8,10-trimethoxydodecahydro-2H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-3(4H)-yl 2-acetamidobenzoate

InChi Key

XTSVKUJYTUPYRJ-QQHZJSBHSA-N

InChi Code

InChI=1S/C32H44N2O9/c1-6-34-16-28(43-26(36)18-9-7-8-10-20(18)33-17(2)35)12-11-24(41-4)31-22-13-19-21(40-3)14-30(38,32(22,39)25(19)42-5)29(37,27(31)34)15-23(28)31/h7-10,19,21-25,27,37-39H,6,11-16H2,1-5H3,(H,33,35)/t19-,21+,22+,23-,24+,25+,27?,28-,29?,30+,31?,32+/m1/s1

SMILES Code

CCN1C[C@]2(OC(c3c(NC(C)=O)cccc3)=O)CC[C@H](OC)C45[C@@H]2CC([C@@]6(O)C[C@H](OC)[C@H]7C[C@@H]5[C@]6(O)[C@H]7OC)(O)C41

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 600.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang L, Miao X, Li Y, Hu F, Ma D, Zhang Z, Sun Q, Zhu Y, Zhu Q. Traditional processing, uses, phytochemistry, pharmacology and toxicology of Aconitum sinomontanum Nakai: A comprehensive review. J Ethnopharmacol. 2022 Jul 15;293:115317. doi: 10.1016/j.jep.2022.115317. Epub 2022 Apr 22. PMID: 35469829. 2: Yan Y, Li X, Wang Z, Yang X, Yin T. C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities. RSC Adv. 2021 Dec 22;12(1):395-405. doi: 10.1039/d1ra08132b. PMID: 35424499; PMCID: PMC8978619. 3: Zhang L, Miao X, Li Y, Dai H, Shang X, Hu F, Fan Q. Toxic and active material basis of Aconitum sinomontanum Nakai based on biological activity guidance and UPLC-Q/TOF-MS technology. J Pharm Biomed Anal. 2020 Sep 5;188:113374. doi: 10.1016/j.jpba.2020.113374. Epub 2020 May 31. PMID: 32563055. 4: Jiang GY, Qin LL, Gao F, Huang S, Zhou XL. Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai. Fitoterapia. 2020 Mar;141:104477. doi: 10.1016/j.fitote.2020.104477. Epub 2020 Jan 10. PMID: 31927015. 5: Kintsurashvili L, Mshvildadze V, Suladze T. [ALKALOIDS OF UNDERGROUND PARTS OF GEORGIAN FLORA'S ACONITUM ORIENTALE MILL. AND ACONITUM NASUTUM FISCH. EX REICHEMB AND THEIR BIOLOGICAL ACTIVITY]. Georgian Med News. 2018 Jan;(274):164-167. Russian. PMID: 29461247. 6: Nie J, Wang F, Ji T, Zhao J, Zhao F. Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication. J Pharm Biomed Anal. 2017 Apr 15;137:84-89. doi: 10.1016/j.jpba.2017.01.003. Epub 2017 Jan 3. PMID: 28104561. 7: Guo T, Zhang Y, Zhao J, Zhu C, Feng N. Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum. J Nanobiotechnology. 2015 Jul 10;13:47. doi: 10.1186/s12951-015-0107-3. PMID: 26156035; PMCID: PMC4496826. 8: Li Y, Zhou JH, Han GJ, Wang MJ, Sun WJ, Zhao Y. X-ray crystallographic study of ranaconitine. Nat Prod Commun. 2011 Nov;6(11):1589-90. PMID: 22224266. 9: Zhou JH, Li Y, Zhang L, Wang DQ. X-ray structure study of ranaconitine hydrobromide. Nat Prod Res. 2012;26(15):1451-3. doi: 10.1080/14786419.2011.603319. Epub 2011 Oct 11. PMID: 21988549. 10: Tan JJ, Tan CH, Ruan BQ, Jiang SH, Zhu DY. Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum. J Asian Nat Prod Res. 2006 Sep;8(6):535-9. doi: 10.1080/10286020500175643. PMID: 16931429. 11: Bello-Ramírez AM, Nava-Ocampo AA. A QSAR analysis of toxicity of Aconitum alkaloids. Fundam Clin Pharmacol. 2004 Dec;18(6):699-704. doi: 10.1111/j.1472-8206.2004.00280.x. PMID: 15548242. 12: Yang F, Ito Y. Preparative separation of lappaconitine, ranaconitine, N-deacetyllappaconitine and N-deacetylranaconitine from crude alkaloids of sample Aconitum sinomontanum Nakai by high-speed counter-current chromatography. J Chromatogr A. 2002 Jan 18;943(2):219-25. doi: 10.1016/s0021-9673(01)01464-9. PMID: 11833641. 13: Wang FP, Peng CS, Jian XX, Chen DL. Five new norditerpenoid alkaloids from Aconitum sinomontanum. J Asian Nat Prod Res. 2001;3(1):15-22. doi: 10.1080/10286020108042834. PMID: 11355766. 14: Ding LS, Wu FE, Chen YZ. [Diterpenoid alkaloids from Aconitum gymnandrum]. Yao Xue Xue Bao. 1993;28(3):188-91. Chinese. PMID: 8368077. 15: Wang R, Ni J. [Diterpenoid alkaloids of Aconitum sinomontanum var. angustius W.T. Wang]. Zhongguo Zhong Yao Za Zhi. 1992 Sep;17(9):549-50, 576. Chinese. PMID: 1292496. 16: De-Quan Y, Das BC. Alkaloids of Aconitum barbatum. Planta Med. 1983 Oct;49(10):85-9. doi: 10.1055/s-2007-969821. PMID: 17405023.