RAC 109 | CAS#17592-97-1 | antiarrhythmic

MedKoo Cat#: 461119 | Name: RAC 109

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RAC 109 is a chiral antiarrhythmic drug.

Chemical Structure

RAC 109

CAS#17592-97-1

Theoretical Analysis

MedKoo Cat#: 461119

Name: RAC 109

CAS#: 17592-97-1

Chemical Formula: C20H28N2O2

Exact Mass: 328.2151

Molecular Weight: 328.45

Elemental Analysis: C, 73.14; H, 8.59; N, 8.53; O, 9.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RAC 109; RAC-109; RAC109;

IUPAC/Chemical Name

1'-(3-(diethylamino)propyl)-3,4-dihydro-2H-spiro[naphthalene-1,3'-pyrrolidine]-2',5'-dione

InChi Key

ZIBPVLWIYWXNMK-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H28N2O2/c1-3-21(4-2)13-8-14-22-18(23)15-20(19(22)24)12-7-10-16-9-5-6-11-17(16)20/h5-6,9,11H,3-4,7-8,10,12-15H2,1-2H3

SMILES Code

CCN(CCCN1C(CC2(CCCc3ccccc32)C1=O)=O)CC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 328.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kariya N, Cosson C, Mazoit JX. Comparative effect of lidocaine, bupivacaine and RAC 109 on myocardial conduction and contractility in the rabbit. Eur J Pharmacol. 2012 Sep 15;691(1-3):110-7. doi: 10.1016/j.ejphar.2012.05.034. Epub 2012 Jun 8. PubMed PMID: 22683876. 2: Freedman TB, Long F, Citra M, Nafie LA. Hydrogen-stretching vibrational circular dichroism spectroscopy: absolute configuration and solution conformation of selected pharmaceutical molecules. Enantiomer. 1999;4(2):103-19. PubMed PMID: 10483713. 3: Tiger G, Fowler CJ. Further validation of a simple biochemical method for evaluation of local anesthetic effects at sodium channels. Methods Find Exp Clin Pharmacol. 1996 Sep;18(7):431-5. PubMed PMID: 8900214. 4: Lee-Son S, Wang GK, Concus A, Crill E, Strichartz G. Stereoselective inhibition of neuronal sodium channels by local anesthetics. Evidence for two sites of action? Anesthesiology. 1992 Aug;77(2):324-35. PubMed PMID: 1322642. 5: Clarkson CW. Stereoselective block of cardiac sodium channels by RAC109 in single guinea pig ventricular myocytes. Circ Res. 1989 Nov;65(5):1306-23. PubMed PMID: 2553294.