R 78206 | CAS#124436-97-1 | poliovirus inhibitor

MedKoo Cat#: 461090 | Name: R78206

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R 78206 is a pyridazinamine derivative that inhibits the formation of poliovirus eclipse particles.

Chemical Structure

R78206

CAS#124436-97-1

Theoretical Analysis

MedKoo Cat#: 461090

Name: R78206

CAS#: 124436-97-1

Chemical Formula: C22H29N3O3

Exact Mass: 383.2209

Molecular Weight: 383.49

Elemental Analysis: C, 68.90; H, 7.62; N, 10.96; O, 12.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

R 78206; R-78206; R78206;

IUPAC/Chemical Name

ethyl 4-(3-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)propoxy)benzoate

InChi Key

UEIUDEUUVLYRFV-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H29N3O3/c1-3-27-22(26)19-7-9-20(10-8-19)28-16-4-5-18-12-14-25(15-13-18)21-11-6-17(2)23-24-21/h6-11,18H,3-5,12-16H2,1-2H3

SMILES Code

Cc1nnc(N(CC2)CCC2CCCOc3ccc(C(OCC)=O)cc3)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 383.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rombaut B, Andries K, Boeyé A. A comparison of WIN 51711 and R 78206 as stabilizers of poliovirus virions and procapsids. J Gen Virol. 1991 Sep;72 ( Pt 9):2153-7. PubMed PMID: 1716654. 2: Ofori-Anyinam O, Vrijsen R, Kronenberger P, Boeyé A. Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus. J Virol. 1993 Apr;67(4):2367-9. PubMed PMID: 8383247; PubMed Central PMCID: PMC240400. 3: Ofori-Anyinam O, Vrijsen R, Kronenberger P, Boeyé A. Poliovirus infection without accumulation of eclipse particles. Antiviral Res. 1995 Jan;26(1):27-35. PubMed PMID: 7741519. 4: Rombaut B, Andries K, Boeyé A. Stabilisation of poliovirus with pirodavir. Dev Biol Stand. 1996;87:173-80. PubMed PMID: 8854015. 5: Ofori-Anyinam O, Vrijsen R, Kronenberger P, Boeyé A. Heat stabilized, infectious poliovirus. Vaccine. 1995 Aug;13(11):983-6. PubMed PMID: 8525692.