Synonym
p-Valerylphenol; NSC 49186; NSC-49186; NSC49186; 4'-Hydroxyvalerophenone; 4-Hydroxyvalerophenone; 4 Hydroxyvalerophenone; 1-pentanone; 1 pentanone
IUPAC/Chemical Name
1-Pentanone, 1-(4-hydroxyphenyl)-
InChi Key
ZKCJJGOOPOIZTE-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H14O2/c1-2-3-4-11(13)9-5-7-10(12)8-6-9/h5-8,12H,2-4H2,1H3
SMILES Code
CCCCC(C1=CC=C(O)C=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
p-Valerylphenol is mainly investigated for its effects on bilayer membranes and lipid components.
In vitro activity:
p-Valerylphenol was investigated alongside other compounds like phloretin and 2-hydroxy-omega-phenylpropiophenone for its effects on membrane structure. When incorporated into membranes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, p-Valerylphenol left the overall bilayer structure intact, caused minor disordering in the hydrocarbon chains, and did not significantly affect the dynamics of the head group. p-Valerylphenol altered the hydration layer at the lipid-water interface, reducing the adsorption of water to the membrane surface.
Reference: Biochemistry. 1991 Apr 23;30(16):3923-9. https://pubmed.ncbi.nlm.nih.gov/1850293/
In vivo activity:
To be determined
Preparing Stock Solutions
The following data is based on the
product
molecular weight
178.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Bechinger B, Seelig J. Interaction of electric dipoles with phospholipid head groups. A 2H and 31P NMR study of phloretin and phloretin analogues in phosphatidylcholine membranes. Biochemistry. 1991 Apr 23;30(16):3923-9. doi: 10.1021/bi00230a017. PMID: 1850293.
In vitro protocol:
1. Bechinger B, Seelig J. Interaction of electric dipoles with phospholipid head groups. A 2H and 31P NMR study of phloretin and phloretin analogues in phosphatidylcholine membranes. Biochemistry. 1991 Apr 23;30(16):3923-9. doi: 10.1021/bi00230a017. PMID: 1850293.
In vivo protocol:
To be determined
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