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MedKoo Cat#: 563405 | Name: MeBIO
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MeBIO is a negative control analog of BIO, and an aryl hydrocarbon receptor (AhR) agonist. It causes redistribution of AhR to the nucleus.

Chemical Structure

MeBIO
MeBIO
CAS#667463-95-8

Theoretical Analysis

MedKoo Cat#: 563405

Name: MeBIO

CAS#: 667463-95-8

Chemical Formula: C17H12BrN3O2

Exact Mass: 369.0113

Molecular Weight: 370.21

Elemental Analysis: C, 55.15; H, 3.27; Br, 21.58; N, 11.35; O, 8.64

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 weeks
25mg USD 650.00 2 weeks
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Related CAS #
No Data
Synonym
MeBIO; Me-BIO; Me BIO;
IUPAC/Chemical Name
(2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
InChi Key
JUKQKURGZYNHFN-NVVUQHMZSA-N
InChi Code
InChI=1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,19,23H,1H3/b16-14-,20-15+
SMILES Code
O=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)N(C)C4=C1C=CC(Br)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B).
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 9.2 24.86
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 370.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Wei F, Diedrich KT, Fullerton HJ, deVeber G, Wintermark M, Hodge J, Kirton A; Vascular Effects of Infection in Pediatric Stroke (VIPS) Investigators. Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis? Stroke. 2016 May;47(5):1265-70. doi: 10.1161/STROKEAHA.115.011331. Epub 2016 Mar 22. PubMed PMID: 27006453; PubMed Central PMCID: PMC4846544. 2: Kato T, Okumura I, Kose H, Takagi K, Hata N. Tendon-driven continuum robot for neuroendoscopy: validation of extended kinematic mapping for hysteresis operation. Int J Comput Assist Radiol Surg. 2016 Apr;11(4):589-602. doi: 10.1007/s11548-015-1310-2. Epub 2015 Oct 17. PubMed PMID: 26476639; PubMed Central PMCID: PMC4993112. 3: Kishi K, Homma S, Nakatani T, Nakata K. [A clinical study of cryptococcal meningitis--sequential changes of cryptococcal antigen titers]. Kansenshogaku Zasshi. 2003 Mar;77(3):150-7. Japanese. PubMed PMID: 12708008. 4: Torreggiani A, Fini G. The binding of biotin analogues by streptavidin: a Raman spectroscopic study. Biospectroscopy. 1998;4(3):197-208. PubMed PMID: 9639110.