MedKoo Cat#: 585039 | Name: PR-D-92

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PR-D-92 is an anti-anaphylactic drug.

Chemical Structure

PR-D-92
PR-D-92
CAS#52156-73-7

Theoretical Analysis

MedKoo Cat#: 585039

Name: PR-D-92

CAS#: 52156-73-7

Chemical Formula: C21H21NO6

Exact Mass: 383.1369

Molecular Weight: 383.40

Elemental Analysis: C, 65.79; H, 5.52; N, 3.65; O, 25.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PR-D-92; PR-D 92EA; Prd-92 Ea
IUPAC/Chemical Name
5,5-Dimethyl-11-oxo-5H,11H-(2)benzopyrano(4,3-g)(1)benzopyran-9-carboxylic acid, compd. with 2-aminoethanol (1:1)
InChi Key
NMNWJAVLNZOTHO-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14O5.C2H7NO/c1-19(2)13-6-4-3-5-10(13)11-7-12-14(20)8-17(18(21)22)23-15(12)9-16(11)24-19;3-1-2-4/h3-9H,1-2H3,(H,21,22);4H,1-3H2
SMILES Code
O=C(C1=CC(C2=CC(C3=CC=CC=C3C(C)(C)O4)=C4C=C2O1)=O)O.NCCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Possanza GJ, Bauen A, Stewart PB. In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA. Int Arch Allergy Appl Immunol. 1975;49(6):789-95. PubMed PMID: 336. 2: Ebner H, Geimer R. [Comparison of fenoterol (Berotec) with the antiallergic benzopyrene compound PR-D 92 and a placebo in regard to the cutaneous immediate reaction in allergic patients (author's transl)]. Wien Med Wochenschr. 1980 Jun 30;130(12):451-5. German. PubMed PMID: 7424031. 3: Chand N, Eyre P. The pharmacology of anaphylaxis in the chicken intestine. Br J Pharmacol. 1976 Jul;57(3):399-408. PubMed PMID: 974319; PubMed Central PMCID: PMC1667235. 4: Beets JL, Meade HM, Morley J. Anti-allergy properties of PRD-92 Ea in guinea pig and rat. Int Arch Allergy Appl Immunol. 1980;61(4):449-56. PubMed PMID: 6444926. 5: Holroyde MC, Eyre P. Modulation of antigen-induced histamine release from bovine granulocytes by several anti-allergic agents. Int Arch Allergy Appl Immunol. 1977;53(6):515-9. PubMed PMID: 68006. 6: Burka JF, Eyre P. Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs. Int Arch Allergy Appl Immunol. 1975;49(6):774-81. PubMed PMID: 811569. 7: Burka JF, Eyre P. Effects of bovine SRS-A (SRS-Abov) on bovine respiratory tract and lung vasculature in vitro. Eur J Pharmacol. 1977 Jul 15;44(2):169-77. PubMed PMID: 885166. 8: Davies PS, Rhodes J, Counsell B, Evans BK. Maintenance of remission in ulcerative colitis. Effect of an orally absorbed mast cell stabilizer. Am J Gastroenterol. 1980 Aug;74(2):150-3. PubMed PMID: 6108711. 9: Burka JF, Eyre P. A pharmacological study of SRS-A on the bovine cutaneous vasculature. Can J Physiol Pharmacol. 1977 Aug;55(4):904-8. PubMed PMID: 902163.