MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 584497 | Name: Decursin
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities. It reduces the growth of B16/F10 murine melanoma cells, via induction of apoptosis and increased caspase-3 activity

Chemical Structure

Decursin
Decursin
CAS#5928-25-6

Theoretical Analysis

MedKoo Cat#: 584497

Name: Decursin

CAS#: 5928-25-6

Chemical Formula: C19H20O5

Exact Mass: 328.1311

Molecular Weight: 328.36

Elemental Analysis: C, 69.50; H, 6.14; O, 24.36

Price and Availability

Size Price Availability Quantity
10mg USD 285.00 2 Weeks
25mg USD 550.00 2 Weeks
50mg USD 850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Decursin; (+)-Decursin; (S)-(+)-Decursin
IUPAC/Chemical Name
3-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester
InChi Key
CUKSFECWKQBVED-INIZCTEOSA-N
InChi Code
InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
SMILES Code
C/C(C)=C\C(O[C@H](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: He L, Pan Y, Yu J, Wang B, Dai G, Ying X. Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway. Int Immunopharmacol. 2021 Aug;97:107657. doi: 10.1016/j.intimp.2021.107657. Epub 2021 Apr 18. PMID: 33878544. 2: Shehzad A, Parveen S, Qureshi M, Subhan F, Lee YS. Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases. Inflamm Res. 2018 Mar;67(3):209-218. doi: 10.1007/s00011-017-1114-7. Epub 2017 Nov 13. PMID: 29134229. 3: Que R, Cao M, Dai Y, Zhou Y, Chen Y, Lin L. Decursin ameliorates carbon- tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells. Biochem Cell Biol. 2022 Oct 1;100(5):378-386. doi: 10.1139/bcb-2022-0027. Epub 2022 Apr 7. PMID: 35785548. 4: Bhat TA, Dheeraj A, Nambiar DK, Singh SP, Yim DS, Singh RP. Decursin inhibits EGFR-ERK1/2 signaling axis in advanced human prostate carcinoma cells. Prostate. 2023 May;83(6):534-546. doi: 10.1002/pros.24482. Epub 2023 Jan 3. PMID: 36597263. 5: Choi H, Yoon JH, Youn K, Jun M. Decursin prevents melanogenesis by suppressing MITF expression through the regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β cascades. Biomed Pharmacother. 2022 Mar;147:112651. doi: 10.1016/j.biopha.2022.112651. Epub 2022 Jan 18. PMID: 35063859. 6: Ge Y, Yoon SH, Jang H, Jeong JH, Lee YM. Decursin promotes HIF-1α proteasomal degradation and immune responses in hypoxic tumour microenvironment. Phytomedicine. 2020 Nov;78:153318. doi: 10.1016/j.phymed.2020.153318. Epub 2020 Sep 1. PMID: 32896707. 7: Kim S, Lee SI, Kim N, Joo M, Lee KH, Lee MW, Jeon HJ, Ryu H, Kim JM, Sul JY, Song GY, Kim JY, Lee HJ. Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C. Am J Cancer Res. 2021 Apr 15;11(4):1304-1320. PMID: 33948359; PMCID: PMC8085838. 8: Zhu J, Dong X. Decursin alleviates LPS-induced lung epithelial cell injury by inhibiting NF-κB pathway activation. Allergol Immunopathol (Madr). 2023 Jan 1;51(1):37-43. doi: 10.15586/aei.v51i1.689. PMID: 36617820. 9: Son DB, Choi W, Kim M, Go EJ, Jeong D, Park CK, Kim YH, Lee H, Suh JW. Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model. Cells. 2021 Mar 4;10(3):547. doi: 10.3390/cells10030547. PMID: 33806325; PMCID: PMC8001788. 10: Zhu ML, Li JC, Wang L, Zhong X, Zhang YW, Tan RZ, Wang HL, Fan JM, Wang L. Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling. J Asian Nat Prod Res. 2021 Jun;23(6):584-595. doi: 10.1080/10286020.2020.1821669. Epub 2020 Nov 25. PMID: 33233968. 11: Wang X, Zheng T, Kang JH, Li H, Cho H, Jeon R, Ryu JH, Yim M. Decursin from Angelica gigas suppresses RANKL-induced osteoclast formation and bone loss. Eur J Pharmacol. 2016 Mar 5;774:34-42. doi: 10.1016/j.ejphar.2016.01.008. Epub 2016 Jan 26. PMID: 26825541. 12: Joo M, Heo JB, Kim S, Kim N, Jeon HJ, An Y, Song GY, Kim JM, Lee HJ. Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expression in vitro. Oncol Rep. 2022 Feb;47(2):39. doi: 10.3892/or.2021.8250. Epub 2021 Dec 27. PMID: 34958113; PMCID: PMC8759107. 13: Kim HJ, Kim SM, Park KR, Jang HJ, Na YS, Ahn KS, Kim SH, Ahn KS. Decursin chemosensitizes human multiple myeloma cells through inhibition of STAT3 signaling pathway. Cancer Lett. 2011 Feb 1;301(1):29-37. doi: 10.1016/j.canlet.2010.11.002. Epub 2010 Nov 30. PMID: 21122982. 14: Lee JK, Jeong JW, Jang T, Lee GW, Han H, Kang JS, Kim IH. Decursin attenuates kainic acid-induced seizures in mice. Neuroreport. 2014 Nov 12;25(16):1243-9. doi: 10.1097/WNR.0000000000000208. PMID: 25171200. 15: Jung SY, Choi JH, Kwon SM, Masuda H, Asahara T, Lee YM. Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function. J Cell Biochem. 2012 May;113(5):1478-87. doi: 10.1002/jcb.24085. PMID: 22298358. 16: Lee TK, Kang IJ, Sim H, Lee JC, Ahn JH, Kim DW, Park JH, Lee CH, Kim JD, Won MH, Choi SY. Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage. Molecules. 2021 Apr 9;26(8):2161. doi: 10.3390/molecules26082161. PMID: 33918660; PMCID: PMC8069195. 17: Oh ST, Lee S, Hua C, Koo BS, Pak SC, Kim DI, Jeon S, Shin BA. Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway. Korean J Physiol Pharmacol. 2019 Jan;23(1):29-35. doi: 10.4196/kjpp.2019.23.1.29. Epub 2018 Dec 26. PMID: 30627007; PMCID: PMC6315092. 18: Li J, Wang H, Wang L, Tan R, Zhu M, Zhong X, Zhang Y, Chen B, Wang L. Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway. Phytother Res. 2018 Dec;32(12):2456-2465. doi: 10.1002/ptr.6184. Epub 2018 Sep 24. PMID: 30251417. 19: Kim JH, Kim JH, Lee YM, Ahn EM, Kim KW, Yu YS. Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation. Mol Vis. 2009 Sep 12;15:1868-75. PMID: 19756180; PMCID: PMC2743803. 20: Chae JW, Baek IH, Kwon KI. Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats. J Ethnopharmacol. 2012 Nov 21;144(2):248-54. doi: 10.1016/j.jep.2012.08.046. Epub 2012 Sep 7. PMID: 22981724.