MedKoo Cat#: 563392 | Name: (R)-SCH-23982 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-SCH-23982 HCl is a D1 antagonist and a precursor of [125I]-(R)-SCH-23982.

Chemical Structure

(R)-SCH-23982 HCl
(R)-SCH-23982 HCl
CAS#300561-61-9

Theoretical Analysis

MedKoo Cat#: 563392

Name: (R)-SCH-23982 HCl

CAS#: 300561-61-9

Chemical Formula: C17H19NO

Exact Mass: 253.1467

Molecular Weight: 253.34

Elemental Analysis: C, 80.60; H, 7.56; N, 5.53; O, 6.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
(R)-SCH-23982 HCl; (R)SCH23982 HCl; (R) SCH 23982 HCl; R-SCH-23982 HCl; (R) SCH 23982 Hydrochloride; (R)SCH23982 Hydrochloride; (R)-(+)-Deschloro-SCH23390 HCl;
IUPAC/Chemical Name
(R)-2,3,4,5-Tetrahydro-8-hydroxy-3-methyl-1-phenyl-1H-3-benzazepine
InChi Key
DNNMNDDMPUSDQC-QGZVFWFLSA-N
InChi Code
InChI=1S/C17H19NO/c1-18-10-9-14-7-8-15(19)11-16(14)17(12-18)13-5-3-2-4-6-13/h2-8,11,17,19H,9-10,12H2,1H3/t17-/m1/s1
SMILES Code
CN1C[C@H](C2=CC=CC=C2)C3=CC(O)=CC=C3CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 253.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shin Y, White BH, Uh M, Sidhu A. Modulation of D1-like dopamine receptor function by aldehydic products of lipid peroxidation. Brain Res. 2003 Apr 4;968(1):102-13. PubMed PMID: 12644268. 2: Sidhu A, Olde B, Humblot N, Kimura K, Gardner N. Regulation of human D1 dopamine receptor function and gene expression in SK-N-MC neuroblastoma cells. Neuroscience. 1999;91(2):537-47. PubMed PMID: 10366011. 3: Sidhu A, Uh M, Sela S, White BH, Kimura K, Patel S. Molecular and structural differences between rat brain D-1 and renal DA-1 dopamine receptors. Neurosci Res. 1997 Sep;29(1):1-8. PubMed PMID: 9293487. 4: Lawler CP, Gilmore JH, Mooney DH, Mayleben MA, Atashi JR, Mileson BE, Wyrick SD, Mailman RB. A rapid and efficient method for the radiosynthesis and purification of [125I]SCH23982. J Neurosci Methods. 1993 Aug;49(1-2):141-53. PubMed PMID: 8271827. 5: Sidhu A, Vachvanichsanong P, Jose PA, Felder RA. Persistent defective coupling of dopamine-1 receptors to G proteins after solubilization from kidney proximal tubules of hypertensive rats. J Clin Invest. 1992 Mar;89(3):789-93. PubMed PMID: 1531836; PubMed Central PMCID: PMC442923. 6: Sidhu A. A novel affinity purification of D-1 dopamine receptors from rat striatum. J Biol Chem. 1990 Jun 15;265(17):10065-72. PubMed PMID: 2141020. 7: Sidhu A, Felder RA, Jose PA, Fishman PH. Comparison of the central and renal dopamine-1 receptor. Am J Hypertens. 1990 Jun;3(6 Pt 2):37S-39S. PubMed PMID: 1974441. 8: Sidhu A, Fishman PH. Identification and characterization of functional D1 dopamine receptors in a human neuroblastoma cell line. Biochem Biophys Res Commun. 1990 Jan 30;166(2):574-9. PubMed PMID: 2154212. 9: Sidhu A. Solubilization and reconstitution of the D-1 dopamine receptor: potentiation of the agonist high-affinity state of the receptor. Biochemistry. 1988 Nov 29;27(24):8768-76. PubMed PMID: 2977287. 10: Kung HF, Billings JJ, Guo YZ, Blau M, Ackerhalt R. Preparation and biodistribution of [125I]IBZP: a potential CNS D-1 dopamine receptor imaging agent. Int J Rad Appl Instrum B. 1988;15(2):187-93. PubMed PMID: 2966781. 11: Agui T, Bryant G, Kebabian JW, Larson S, Saavedra JM, Shigematsu K, Yamamoto T, Yokoyama K. 125I-iodinated benzazepines bind to melanin: implications for the noninvasive localization of pigmented melanomas. Int J Rad Appl Instrum B. 1987;14(2):133-41. PubMed PMID: 2885295.