MedKoo Cat#: 414867 | Name: DEPC
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DEPC, also known as DC22:1PC or SJN79954, is a phospholipid containing erucic acid at the sn-1 and sn-2 positions. DEPC is a useful reagent in drug formulation study. DEPC was used in FDA approved Exparel®, a multivesicular liposome formulation for the extensive release of bupivacaine

Chemical Structure

DEPC
DEPC
CAS#51779-95-4

Theoretical Analysis

MedKoo Cat#: 414867

Name: DEPC

CAS#: 51779-95-4

Chemical Formula: C52H100NO8P

Exact Mass: 897.7187

Molecular Weight: 898.34

Elemental Analysis: C, 69.52; H, 11.22; N, 1.56; O, 14.25; P, 3.45

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
250mg USD 650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
DEPC, 1,2-DEPC; DC22:1PC; DC22:1PC; PC(22:1/22:1); SJN79954; SJN-79954; SJN 79954; Dierucoyl Phosphatidylcholine; L-Dierucoyl lecithin; Dierucoyllecithin; DEPC, L-
IUPAC/Chemical Name
1,2-Dierucoyl-sn-glycero-3-phosphocholine
InChi Key
SDEURMLKLAEUAY-JFSPZUDSSA-N
InChi Code
InChI=1S/C52H100NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h20-23,50H,6-19,24-49H2,1-5H3/b22-20-,23-21-/t50-/m1/s1
SMILES Code
CCCCCCCC/C=C\CCCCCCCCCCCC(O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)=O
Appearance
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in ethanol (up to 30mg/mL)
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
[Vyas et al.,Systematic Review of Liposomal Bupivacaine (Exparel) for Postoperative Analgesia Plastic and Reconstructive Surgery, 2016 doi.org/10.1097/PRS.0000000000002547].

Preparing Stock Solutions

The following data is based on the product molecular weight 898.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sun D, Peyear TA, Bennett WFD, Holcomb M, He S, Zhu F, Lightstone FC, Andersen OS, Ingólfsson HI. Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based In Silico and In Vitro Assays. J Med Chem. 2020 Oct 22;63(20):11809-11818. doi: 10.1021/acs.jmedchem.0c00958. Epub 2020 Oct 1. PMID: 32945672; PMCID: PMC7586341. 2: Sun D, Peyear TA, Bennett WFD, Andersen OS, Lightstone FC, Ingólfsson HI. Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness. Biophys J. 2019 Nov 19;117(10):1831-1844. doi: 10.1016/j.bpj.2019.09.044. Epub 2019 Oct 10. PMID: 31676135; PMCID: PMC7018991. 3: Lum K, Ingólfsson HI, Koeppe RE 2nd, Andersen OS. Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel Formation. Biophys J. 2017 Oct 17;113(8):1757-1767. doi: 10.1016/j.bpj.2017.08.049. PMID: 29045870; PMCID: PMC5647621. 4: Su CJ, Wu SS, Jeng US, Lee MT, Su AC, Liao KF, Lin WY, Huang YS, Chen CY. Peptide-induced bilayer thinning structure of unilamellar vesicles and the related binding behavior as revealed by X-ray scattering. Biochim Biophys Acta. 2013 Feb;1828(2):528-34. doi: 10.1016/j.bbamem.2012.10.027. Epub 2012 Nov 1. PMID: 23123565. 5: Tristram-Nagle S, Chan R, Kooijman E, Uppamoochikkal P, Qiang W, Weliky DP, Nagle JF. HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics. J Mol Biol. 2010 Sep 10;402(1):139-53. doi: 10.1016/j.jmb.2010.07.026. Epub 2010 Jul 22. PMID: 20655315; PMCID: PMC2940274. 6: Sobko AA, Kotova EA, Antonenko YN, Zakharov SD, Cramer WA. Lipid dependence of the channel properties of a colicin E1-lipid toroidal pore. J Biol Chem. 2006 May 19;281(20):14408-16. doi: 10.1074/jbc.M513634200. Epub 2006 Mar 23. PMID: 16556601. 7: Word RC, Smejtek P. Partitioning of tetrachlorophenol into lipid bilayers and sarcoplasmic reticulum: effect of length of acyl chains, carbonyl group of lipids and biomembrane structure. J Membr Biol. 2005 Feb;203(3):127-42. doi: 10.1007/s00232-005-0737-8. PMID: 15986092. 8: Weber ME, Schlesinger PH, Gokel GW. Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths. J Am Chem Soc. 2005 Jan 19;127(2):636-42. doi: 10.1021/ja044936+. PMID: 15643888; PMCID: PMC2615579. 9: Fernandes F, Loura LM, Prieto M, Koehorst R, Spruijt RB, Hemminga MA. Dependence of M13 major coat protein oligomerization and lateral segregation on bilayer composition. Biophys J. 2003 Oct;85(4):2430-41. doi: 10.1016/S0006-3495(03)74666-9. PMID: 14507706; PMCID: PMC1303467. 10: Wulf J, Pohl WG. Calcium ion-flux across phosphatidylcholine membranes mediated by ionophore A23187. Biochim Biophys Acta. 1977 Mar 17;465(3):471-85. doi: 10.1016/0005-2736(77)90266-8. PMID: 13833.