VU 0650786 | CAS# | Antidepressant

MedKoo Cat#: 571267 | Name: VU 0650786

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU 0650786 is a mGlu3 negative allosteric modulator. VU 0650786 has an mGlu2 IC50 of greater than 30 uM and mGlu3 IC50 of 392 nM, suggesting that it is highly selective for mGlu2 and mGlu3.

Chemical Structure

VU 0650786

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 571267

Name: VU 0650786

CAS#: NONE

Chemical Formula: C18H15ClFN5O2

Exact Mass: 387.0898

Molecular Weight: 387.80

Elemental Analysis: C, 55.75; H, 3.90; Cl, 9.14; F, 4.90; N, 18.06; O, 8.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VU 0650786; VU-0650786; VU0650786

IUPAC/Chemical Name

(R)-2-(((5-chloropyridin-2-yl)oxy)methyl)-5-(2-fluoropyridin-3-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

InChi Key

RXRVCJFGSOVYLG-LLVKDONJSA-N

InChi Code

InChI=1S/C18H15ClFN5O2/c1-11-9-24(14-3-2-6-21-17(14)20)18(26)15-7-13(23-25(11)15)10-27-16-5-4-12(19)8-22-16/h2-8,11H,9-10H2,1H3/t11-/m1/s1

SMILES Code

ClC1=CC=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)N=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Negative allosteric modulators (NAM) are molecules of interest in treating depression-related behaviors, as potentially novel antidepressants.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Engers JL, Bollinger KA; Weiner RL, Rodriguez AL, Long MF, Breiner MM, Chang S, Bollinger SR, Bubser M, Jones CK, Morrison RD, Bridges TM, Blobaum AL, Niswender CM, Conn JP, Emmitte KA, Lindsley CW. Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem. 2017 Aug 15. doi: 10.1021/acsmedchemlett.7b00249. [Epub ahead of print]. 2: Engers JL, Rodriguez AL, Konkol LC, Morrison RD, Thompson AD, Byers FW, Blobaum AL, Chang S, Venable DF, Loch MT, Niswender CM, Daniels JS, Jones CK, Conn PJ, Lindsley CW, Emmitte KA. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500. doi: 10.1021/acs.jmedchem.5b01005. Epub 2015 Sep 10. PubMed PMID: 26335039; PubMed Central PMCID: PMC4809247. 3: Walker AG, Sheffler DJ, Lewis AS, Dickerson JW, Foster DJ, Senter RK, Moehle MS, Lv X, Stansley BJ, Xiang Z, Rook JM, Emmitte KA, Lindsley CW, Conn PJ. Co-Activation of Metabotropic Glutamate Receptor 3 and Beta Adrenergic Receptors Modulates Cyclic-AMP, Long-Term Potentiation, and Disrupts Memory Reconsolidation. Neuropsychopharmacology. 2017 Jun 30. doi: 10.1038/npp.2017.136. [Epub ahead of print] PubMed PMID: 28664928.