WLB-87848 is a Selective σ1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity. WLB-87848 shows good physicochemical and ADMET characteristics, displays an agonist profile in the binding immunoglobulin protein/σ1R association assay, induces neuron viability in an in vitro model of β-amyloid peptide intoxication, and presents positive results against recognition memory impairment induced by hippocampal injection of Aβ peptide in rats after oral treatment, altogether making WLB-87848 an interesting candidate for neuroprotection.
MedKoo Cat#: 127029
Name: WLB-87848
CAS#: N/A
Chemical Formula: C17H15F2N3OS
Exact Mass: 347.0904
Molecular Weight: 347.38
Elemental Analysis: C, 58.78; H, 4.35; F, 10.94; N, 12.10; O, 4.61; S, 9.23
The following data is based on the product molecular weight 347.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
