MedKoo Cat#: 558453 | Name: Papaveraldine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Papaveraldine is a degradation product of papaverine and known benzylisoquinoline alkaloid.

Chemical Structure

Papaveraldine
Papaveraldine
CAS#522-57-6

Theoretical Analysis

MedKoo Cat#: 558453

Name: Papaveraldine

CAS#: 522-57-6

Chemical Formula: C20H19NO5

Exact Mass: 353.1300

Molecular Weight: 353.37

Elemental Analysis: C, 67.98; H, 5.42; N, 3.96; O, 22.64

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Papaveraldine; Papaveraldine; Xanthaline;
IUPAC/Chemical Name
(6,7-Dimethoxy-1-isoquinolyl) (3,4-dimethoxyphenyl) ketone
InChi Key
QJTBIAMBPGGIGI-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H19NO5/c1-23-15-6-5-13(10-16(15)24-2)20(22)19-14-11-18(26-4)17(25-3)9-12(14)7-8-21-19/h5-11H,1-4H3
SMILES Code
O=C(C1=NC=CC2=C1C=C(OC)C(OC)=C2)C3=CC=C(OC)C(OC)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Piotrowska K, Hermann TW, Augustyniak W. Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions. Acta Pol Pharm. 2002 Sep-Oct;59(5):359-64. PubMed PMID: 12602797. 2: Colautti A, Fontani F, Maurich V. HPLC determination of papaveraldine and papaverinol in papaverine injection. J Pharm Biomed Anal. 1987;5(5):493-9. PubMed PMID: 16867493. 3: MACHOVICOVA F, PARRAK V. [Paper chromatographic separation of papaverine, papaverinol & papaveraldine]. Pharmazie. 1959 Jan;14(1):10-2. German. PubMed PMID: 13657671. 4: KREPINSKY J. [Spectrophotometric and colorimetric determination of papverinol and papaveraldine in papaverine]. Cesk Farm. 1962 May 5;11:205-10. Czech. PubMed PMID: 14459579. 5: MERCIER F, MERCIER J, SESTIER MR. [Experimental spasmolytic action of papaverinol and papaveraldine, secondary alkaloids prepared during papaverine synthesis]. C R Seances Soc Biol Fil. 1951 Mar;145(5-6):408-10. Undetermined Language. PubMed PMID: 14849079. 6: El Sayed KA. Microbial transformation of papaveraldine. Phytochemistry. 2000 Mar;53(6):675-8. PubMed PMID: 10746880. 7: Postaire E, Oulare B, Pradeau D, Hamon M. [Simultaneous assay of papaverine and papaveraldine. Applications to the control of pharmaceutical preparations and kinetic study of oxidation reactions]. Ann Pharm Fr. 1985;43(6):547-56. French. PubMed PMID: 3838030. 8: Maurich V, Moneghini M. [HPLC separation of papaverine hydrochloride and its degradation products papaveraldine and papaverinol. Quantitative determination in vials and granules]. Boll Chim Farm. 1983 Jul;122(7):322-9. Italian. PubMed PMID: 6651970. 9: Habashy GM, Farid NA. Thin-layer chromatographic method for separation and determination of papaverine and its oxidation products. Talanta. 1973 Jul;20(7):699-702. PubMed PMID: 18961335. 10: Anselmi E, Fayos G, Blasco R, Candenas L, Cortes D, D'Ocon P. Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle. J Pharm Pharmacol. 1992 Apr;44(4):337-43. PubMed PMID: 1355547. 11: Piotrowska K, Hermann TW, Augustyniak W. Kinetics of photooxidation of papaverine hydrochloride and its major photooxidation products. J Pharm Biomed Anal. 2006 Jun 16;41(4):1391-5. Epub 2006 Mar 31. PubMed PMID: 16580169. 12: Pingaew R, Prachayasittikul S, Ruchirawat S. Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds. Molecules. 2010 Feb 23;15(2):988-96. doi: 10.3390/molecules15020988. PubMed PMID: 20335957. 13: Girreser U, Hermann TW, Piotrowska K. Oxidation and degradation products of papaverine. Part II[1]: investigations on the photochemical degradation of papaverine solutions. Arch Pharm (Weinheim). 2003 Sep;336(9):401-5. PubMed PMID: 14528487. 14: Pohloudek-Fabini R, Gundermann P. [Contribution to the stability of papaverine. Part 2: Quantitative determination of papaverine in the presence of degradation products (author's transl)]. Pharmazie. 1979;34(2):75-6. German. PubMed PMID: 441109.