Synonym
                                        Papaveraldine; Papaveraldine; Xanthaline;
                                     
                                    
                                        IUPAC/Chemical Name
                                        (6,7-Dimethoxy-1-isoquinolyl) (3,4-dimethoxyphenyl) ketone
                                     
                                    
                                        InChi Key
                                        QJTBIAMBPGGIGI-UHFFFAOYSA-N
                                     
                                    
                                        InChi Code
                                        InChI=1S/C20H19NO5/c1-23-15-6-5-13(10-16(15)24-2)20(22)19-14-11-18(26-4)17(25-3)9-12(14)7-8-21-19/h5-11H,1-4H3
                                     
                                    
                                        SMILES Code
                                        O=C(C1=NC=CC2=C1C=C(OC)C(OC)=C2)C3=CC=C(OC)C(OC)=C3
                                     
                                    
                                    
                                        Purity
                                        >98% (or refer to the Certificate of Analysis)
                                     
                                    
                                        Shipping Condition
                                        Shipped under ambient temperature as non-hazardous chemical.  This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
                                     
                                    
                                        Storage Condition
                                        Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
                                     
                                    
                                        Solubility
                                        Soluble in DMSO
                                     
                                    
                                        Shelf Life
                                        >3 years if stored properly
                                     
                                    
                                        Drug Formulation
                                        This drug may be formulated in DMSO
                                     
                                    
                                        Stock Solution Storage
                                        0 - 4 C for short term (days to weeks), or -20 C for long term (months).
                                     
                                    
                                        HS Tariff Code
                                        2934.99.03.00
                                     
                                    
                                 
                             
                            
                                                        
                                                                
                                    Preparing Stock Solutions
                                    
                                        The following data is based on the
                                        product
                                        molecular weight
                                        353.37
                                        Batch specific molecular weights may vary
                                        from batch to batch
                                        due to the degree of hydration, which will
                                        affect the solvent
                                        volumes required to prepare stock solutions.
                                    
                                    
                                    
                                        
                                            
                                            
                                                | Concentration / Solvent Volume / Mass | 
                                                1 mg | 
                                                5 mg | 
                                                10 mg | 
                                            
                                            
                                            
                                            
                                                | 1 mM | 
                                                1.15 mL | 
                                                5.76 mL | 
                                                11.51 mL | 
                                            
                                            
                                                | 5 mM | 
                                                0.23 mL | 
                                                1.15 mL | 
                                                2.3 mL | 
                                            
                                            
                                                | 10 mM | 
                                                0.12 mL | 
                                                0.58 mL | 
                                                1.15 mL | 
                                            
                                            
                                                | 50 mM | 
                                                0.02 mL | 
                                                0.12 mL | 
                                                0.23 mL | 
                                            
                                            
                                        
                                     
                                 
                                                             
                            
                            
                                
                                    1: Piotrowska K, Hermann TW, Augustyniak W. Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions. Acta Pol Pharm. 2002 Sep-Oct;59(5):359-64. PubMed PMID: 12602797.
2: Colautti A, Fontani F, Maurich V. HPLC determination of papaveraldine and papaverinol in papaverine injection. J Pharm Biomed Anal. 1987;5(5):493-9. PubMed PMID: 16867493.
3: MACHOVICOVA F, PARRAK V. [Paper chromatographic separation of papaverine, papaverinol & papaveraldine]. Pharmazie. 1959 Jan;14(1):10-2. German. PubMed PMID: 13657671.
4: KREPINSKY J. [Spectrophotometric and colorimetric determination of papverinol  and papaveraldine in papaverine]. Cesk Farm. 1962 May 5;11:205-10. Czech. PubMed  PMID: 14459579.
5: MERCIER F, MERCIER J, SESTIER MR. [Experimental spasmolytic action of papaverinol and papaveraldine, secondary alkaloids prepared during papaverine synthesis]. C R Seances Soc Biol Fil. 1951 Mar;145(5-6):408-10. Undetermined Language. PubMed PMID: 14849079.
6: El Sayed KA. Microbial transformation of papaveraldine. Phytochemistry. 2000 Mar;53(6):675-8. PubMed PMID: 10746880.
7: Postaire E, Oulare B, Pradeau D, Hamon M. [Simultaneous assay of papaverine and papaveraldine. Applications to the control of pharmaceutical preparations and kinetic study of oxidation reactions]. Ann Pharm Fr. 1985;43(6):547-56. French. PubMed PMID: 3838030.
8: Maurich V, Moneghini M. [HPLC separation of papaverine hydrochloride and its degradation products papaveraldine and papaverinol. Quantitative determination in vials and granules]. Boll Chim Farm. 1983 Jul;122(7):322-9. Italian. PubMed PMID: 6651970.
9: Habashy GM, Farid NA. Thin-layer chromatographic method for separation and determination of papaverine and its oxidation products. Talanta. 1973 Jul;20(7):699-702. PubMed PMID: 18961335.
10: Anselmi E, Fayos G, Blasco R, Candenas L, Cortes D, D'Ocon P. Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle.  J Pharm Pharmacol. 1992 Apr;44(4):337-43. PubMed PMID: 1355547.
11: Piotrowska K, Hermann TW, Augustyniak W. Kinetics of photooxidation of papaverine hydrochloride and its major photooxidation products. J Pharm Biomed Anal. 2006 Jun 16;41(4):1391-5. Epub 2006 Mar 31. PubMed PMID: 16580169.
12: Pingaew R, Prachayasittikul S, Ruchirawat S. Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and  related compounds. Molecules. 2010 Feb 23;15(2):988-96. doi: 10.3390/molecules15020988. PubMed PMID: 20335957.
13: Girreser U, Hermann TW, Piotrowska K. Oxidation and degradation products of papaverine. Part II[1]: investigations on the photochemical degradation of papaverine solutions. Arch Pharm (Weinheim). 2003 Sep;336(9):401-5. PubMed PMID:  14528487.
14: Pohloudek-Fabini R, Gundermann P. [Contribution to the stability of papaverine. Part 2: Quantitative determination of papaverine in the presence of degradation products (author's transl)]. Pharmazie. 1979;34(2):75-6. German. PubMed PMID: 441109.