MedKoo Cat#: 576126 | Name: Pamatolol sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pamatolol sulfate is a cardioselective beta adrenoceptor blocking drug.

Chemical Structure

Pamatolol sulfate
Pamatolol sulfate
CAS#59954-01-7

Theoretical Analysis

MedKoo Cat#: 576126

Name: Pamatolol sulfate

CAS#: 59954-01-7

Chemical Formula: C32H54N4O12S

Exact Mass: 718.3459

Molecular Weight: 718.86

Elemental Analysis: C, 53.47; H, 7.57; N, 7.79; O, 26.71; S, 4.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
H 104/08; Pamatolol sulfate
IUPAC/Chemical Name
methyl (4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamate hemisulfate
InChi Key
OUXGIOLQOYAZLS-UHFFFAOYSA-N
InChi Code
InChI=1S/2C16H26N2O4.H2O4S/c2*1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3;1-5(2,3)4/h2*4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20);(H2,1,2,3,4)
SMILES Code
COC(=O)NCCc1ccc(OCC(O)CNC(C)C)cc1.COC(=O)NCCc2ccc(OCC(O)CNC(C)C)cc2.OS(=O)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 718.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Johansson B. Effects of atenolol, metroprolol, and pamatolol on cardiac and vascular beta-adrenoceptors in the rat. J Cardiovasc Pharmacol. 1979 May-Jun;1(3):287-98. PubMed PMID: 94397. 2: Carruthers SG, Hosler JP, Pentikainen P, Azarnoff DL. Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug. Clin Pharmacol Ther. 1978 Aug;24(2):168-74. PubMed PMID: 28193. 3: Hoffmann KJ, Skånberg I, Borg KO. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73. PubMed PMID: 43252. 4: Hoffmann K. Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol. Acta Pharm Suec. 1979;16(2):160. PubMed PMID: 38629. 5: Carruthers SG, Pentikainen P, Hosler JP, Azarnoff DL. Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker. Clin Pharmacol Ther. 1979 Dec;26(6):682-5. PubMed PMID: 40725. 6: Björgell P, Belfrage P. Characteristics of the lipolytic beta-adrenergic receptors in hamster adipocytes. Biochim Biophys Acta. 1982 Oct 14;713(1):80-5. PubMed PMID: 6128033. 7: Jackson CD, Fishbein L. A toxicological review of beta-adrenergic blockers. Fundam Appl Toxicol. 1986 Apr;6(3):395-422. Review. PubMed PMID: 2870945. 8: Ban T, Sada S, Takahashi Y, Sada H, Fujita T. Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1985 Mar;329(1):77-85. PubMed PMID: 2582279. 9: Ahrén B, Lundquist I. Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo. Eur J Pharmacol. 1981 Apr 24;71(1):93-104. PubMed PMID: 6113155. 10: Hedberg A, Mattsson H. Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle. J Pharmacol Exp Ther. 1981 Dec;219(3):798-808. PubMed PMID: 6117657. 11: Mattsson H, Andersson T, Carlsson E, Hedberg A, Lundgren B, Olsson T. beta 1-and beta 2-adrenoceptor stimulatory effects of prenalterol. Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):302-8. PubMed PMID: 6132344. 12: Carlsöö B, Danielsson A, Henriksson R. Beta 1- and beta 2-adrenoceptor-mediated secretion of amylase from incubated rat parotid gland. Acta Physiol Scand. 1984 Mar;120(3):429-35. PubMed PMID: 6204505. 13: Gyllenhaal O, Vessman J. Gas chromatography with nitrogen-selective detection of metoprolol from human plasma after reaction with phosgene. J Chromatogr. 1983 Mar 11;273(1):129-39. PubMed PMID: 6853642.