Synonym
                                        H 104/08; Pamatolol sulfate
                                     
                                    
                                        IUPAC/Chemical Name
                                        methyl (4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamate hemisulfate
                                     
                                    
                                        InChi Key
                                         OUXGIOLQOYAZLS-UHFFFAOYSA-N
                                     
                                    
                                        InChi Code
                                         InChI=1S/2C16H26N2O4.H2O4S/c2*1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3;1-5(2,3)4/h2*4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20);(H2,1,2,3,4)
                                     
                                    
                                        SMILES Code
                                        COC(=O)NCCc1ccc(OCC(O)CNC(C)C)cc1.COC(=O)NCCc2ccc(OCC(O)CNC(C)C)cc2.OS(=O)(=O)O
                                     
                                    
                                    
                                        Purity
                                        >98% (or refer to the Certificate of Analysis)
                                     
                                    
                                        Shipping Condition
                                        Shipped under ambient temperature as non-hazardous chemical.  This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
                                     
                                    
                                        Storage Condition
                                        Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
                                     
                                    
                                        Solubility
                                        Soluble in DMSO
                                     
                                    
                                        Shelf Life
                                        >2 years if stored properly
                                     
                                    
                                        Drug Formulation
                                        This drug may be formulated in DMSO
                                     
                                    
                                        Stock Solution Storage
                                        0 - 4 C for short term (days to weeks), or -20 C for long term (months).
                                     
                                    
                                        HS Tariff Code
                                        2934.99.9001
                                     
                                    
                                 
                             
                            
                                                        
                                                                    
                                        
                                            
                                                
                                                     | 
                                                    Solvent | 
                                                    mg/mL | 
                                                    mM | 
                                                    comments | 
                                                
                                            
                                            
                                            
                                                | Solubility | 
                                            
                                                                                            
                                                    | Soluble in DMSO | 
                                                    0.0 | 
                                                    100.00 | 
                                                     | 
                                                
                                                                                        
                                        
                                        
                                            Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
                                        
                                     
                                                                
                                    Preparing Stock Solutions
                                    
                                        The following data is based on the
                                        product
                                        molecular weight
                                        718.86
                                        Batch specific molecular weights may vary
                                        from batch to batch
                                        due to the degree of hydration, which will
                                        affect the solvent
                                        volumes required to prepare stock solutions.
                                    
                                    
                                    
                                        
                                            
                                            
                                                | Concentration / Solvent Volume / Mass | 
                                                1 mg | 
                                                5 mg | 
                                                10 mg | 
                                            
                                            
                                            
                                            
                                                | 1 mM | 
                                                1.15 mL | 
                                                5.76 mL | 
                                                11.51 mL | 
                                            
                                            
                                                | 5 mM | 
                                                0.23 mL | 
                                                1.15 mL | 
                                                2.3 mL | 
                                            
                                            
                                                | 10 mM | 
                                                0.12 mL | 
                                                0.58 mL | 
                                                1.15 mL | 
                                            
                                            
                                                | 50 mM | 
                                                0.02 mL | 
                                                0.12 mL | 
                                                0.23 mL | 
                                            
                                            
                                        
                                     
                                 
                                                             
                            
                            
                                
                                    1: Johansson B. Effects of atenolol, metroprolol, and pamatolol on cardiac and vascular beta-adrenoceptors in the rat. J Cardiovasc Pharmacol. 1979 May-Jun;1(3):287-98. PubMed PMID: 94397.
2: Carruthers SG, Hosler JP, Pentikainen P, Azarnoff DL. Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug. Clin Pharmacol Ther. 1978 Aug;24(2):168-74. PubMed PMID: 28193.
3: Hoffmann KJ, Skånberg I, Borg KO. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73. PubMed PMID: 43252.
4: Hoffmann K. Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol. Acta Pharm Suec. 1979;16(2):160. PubMed PMID: 38629.
5: Carruthers SG, Pentikainen P, Hosler JP, Azarnoff DL. Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker. Clin Pharmacol Ther. 1979 Dec;26(6):682-5. PubMed PMID: 40725.
6: Björgell P, Belfrage P. Characteristics of the lipolytic beta-adrenergic receptors in hamster adipocytes. Biochim Biophys Acta. 1982 Oct 14;713(1):80-5. PubMed PMID: 6128033.
7: Jackson CD, Fishbein L. A toxicological review of beta-adrenergic blockers. Fundam Appl Toxicol. 1986 Apr;6(3):395-422. Review. PubMed PMID: 2870945.
8: Ban T, Sada S, Takahashi Y, Sada H, Fujita T. Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1985 Mar;329(1):77-85. PubMed PMID: 2582279.
9: Ahrén B, Lundquist I. Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo. Eur J Pharmacol. 1981 Apr 24;71(1):93-104. PubMed PMID: 6113155.
10: Hedberg A, Mattsson H. Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle. J Pharmacol Exp Ther. 1981 Dec;219(3):798-808. PubMed PMID: 6117657.
11: Mattsson H, Andersson T, Carlsson E, Hedberg A, Lundgren B, Olsson T. beta 1-and beta 2-adrenoceptor stimulatory effects of prenalterol. Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):302-8. PubMed PMID: 6132344.
12: Carlsöö B, Danielsson A, Henriksson R. Beta 1- and beta 2-adrenoceptor-mediated secretion of amylase from incubated rat parotid gland. Acta Physiol Scand. 1984 Mar;120(3):429-35. PubMed PMID: 6204505.
13: Gyllenhaal O, Vessman J. Gas chromatography with nitrogen-selective detection of metoprolol from human plasma after reaction with phosgene. J Chromatogr. 1983  Mar 11;273(1):129-39. PubMed PMID: 6853642.