MedKoo Cat#: 527772 | Name: 2-Methylserotonin maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-Methylserotonin maleate is a selective full agonist at the 5-HT3 receptor.

Chemical Structure

2-Methylserotonin maleate
2-Methylserotonin maleate
CAS#78263-91-9

Theoretical Analysis

MedKoo Cat#: 527772

Name: 2-Methylserotonin maleate

CAS#: 78263-91-9

Chemical Formula: C15H18N2O5

Exact Mass: 306.1216

Molecular Weight: 306.32

Elemental Analysis: C, 58.82; H, 5.92; N, 9.15; O, 26.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
2-Methylserotonin maleate
IUPAC/Chemical Name
3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol Maleate
InChi Key
KFEAUMZKRNJEDU-BTJKTKAUSA-N
InChi Code
InChI=1S/C11H14N2O.C4H4O4/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7;5-3(6)1-2-4(7)8/h2-3,6,13-14H,4-5,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
OC1=CC2=C(NC(C)=C2CCN)C=C1.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 306.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ishizuka O, Gu B, Igawa Y, Nishizawa O, Pehrson R, Andersson KE. Role of supraspinal serotonin receptors for micturition in normal conscious rats. Neurourol Urodyn. 2002;21(3):225-30. PubMed PMID: 11948716. 2: Paul D, Yao D, Zhu P, Minor LD, Garcia MM. 5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach. J Pharmacol Exp Ther. 2001 Aug;298(2):674-8. PubMed PMID: 11454930. 3: Martin SM, Wilson BC, Chen X, Takahashi Y, Poulin P, Pittman QJ. Vagal CCK and 5-HT(3) receptors are unlikely to mediate LPS or IL-1beta-induced fever. Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R960-5. PubMed PMID: 10956254. 4: Ormazábal MJ, Goicoechea C, Alfaro MJ, Sánchez E, Martín MI. Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors. Brain Res. 1999 Oct 23;845(2):130-8. PubMed PMID: 10536192. 5: Carter D, Champney M, Hwang B, Eglen RM. Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur J Pharmacol. 1995 Jul 14;280(3):243-50. PubMed PMID: 8566092. 6: Xu W, Qiu XC, Han JS. Serotonin receptor subtypes in spinal antinociception in the rat. J Pharmacol Exp Ther. 1994 Jun;269(3):1182-9. PubMed PMID: 8014862. 7: Benloucif S, Keegan MJ, Galloway MP. Serotonin-facilitated dopamine release in vivo: pharmacological characterization. J Pharmacol Exp Ther. 1993 Apr;265(1):373-7. PubMed PMID: 8474019. 8: Cohen ML, Bloomquist W, Gidda JS, Lacefield W. LY277359 maleate: a potent and selective 5-HT3 receptor antagonist without gastroprokinetic activity. J Pharmacol Exp Ther. 1990 Jul;254(1):350-5. PubMed PMID: 2366187.