(-)-Quinpirole HCl | CAS#85798-08-9 | D2 agonist

MedKoo Cat#: 563374 | Name: (-)-Quinpirole HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(-)-Quinpirole HCl is the most widely used D2 agonist in in vivo and in vitro studies.

Chemical Structure

(-)-Quinpirole HCl

CAS#85798-08-9 (free base)

Theoretical Analysis

MedKoo Cat#: 563374

Name: (-)-Quinpirole HCl

CAS#: 85798-08-9 (free base)

Chemical Formula: C13H22ClN3

Exact Mass: 255.1502

Molecular Weight: 255.79

Elemental Analysis: C, 61.04; H, 8.67; Cl, 13.86; N, 16.43

Price and Availability

Size	Price	Availability
10mg	USD 400.00	2 weeks
25mg	USD 750.00	2 weeks
100mg	USD 1,700.00	2 weeks

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Related CAS #

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Synonym

(-)-Quinpirole hydrochloride; (-)Quinpirole hydrochloride; (-)-Quinpirole HCl; (-)Quinpirole HCl; (-) Quinpirole HCl; LY-171555; LY 171555; LY171555;

IUPAC/Chemical Name

(4aR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline hydrochloride

InChi Key

HJHVRVJTYPKTHX-HTMVYDOJSA-N

InChi Code

InChI=1S/C13H21N3.ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;/h9-10,13H,2-8H2,1H3,(H,14,15);1H/t10-,13-;/m1./s1

SMILES Code

CCCN1CCC[C@@H]2CC(NN=C3)=C3C[C@@H]12.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 255.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys. J Pharmacol Exp Ther. 2007 Jun;321(3):1135-43. doi: 10.1124/jpet.107.120766. Epub 2007 Mar 9. PMID: 17351103. 11: Nowak P, Labus Ł, Kostrzewa RM, Brus R. DSP-4 prevents dopamine receptor priming by quinpirole. Pharmacol Biochem Behav. 2006 May;84(1):3-7. doi: 10.1016/j.pbb.2006.03.024. Epub 2006 May 3. PMID: 16675001. 12: Collins GT, Witkin JM, Newman AH, Svensson KA, Grundt P, Cao J, Woods JH. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior. J Pharmacol Exp Ther. 2005 Jul;314(1):310-9. doi: 10.1124/jpet.105.085472. Epub 2005 Apr 15. PMID: 15833897; PMCID: PMC1201434. 13: Brown RW, Thompson KN, Click IA, Best RA, Thacker SK, Perna MK. The effects of eticlopride on Morris water task performance in male and female rats neonatally treated with quinpirole. Psychopharmacology (Berl). 2005 Jul;180(2):234-40. doi: 10.1007/s00213-005-2148-z. Epub 2005 Feb 5. PMID: 15696328. 14: Smith DG, Tzavara ET, Shaw J, Luecke S, Wade M, Davis R, Salhoff C, Nomikos GG, Gehlert DR. Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. J Neurosci. 2005 Jan 26;25(4):914-22. doi: 10.1523/JNEUROSCI.4079-04.2005. PMID: 15673672; PMCID: PMC6725636. 15: Zarrindast MR, Rezayof A. Morphine state-dependent learning: sensitization and interactions with dopamine receptors. Eur J Pharmacol. 2004 Aug 23;497(2):197-204. doi: 10.1016/j.ejphar.2004.06.041. PMID: 15306205. 16: Brus R, Kostrzewa RM, Nowak P, Perry KW, Kostrzewa JP. Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats. Neurotox Res. 2003;5(5):329-38. doi: 10.1007/BF03033153. PMID: 14715452. 17: Kline DD, Takacs KN, Ficker E, Kunze DL. Dopamine modulates synaptic transmission in the nucleus of the solitary tract. 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