ZLD-2 is a Potent Dual EZH2−BRD4 Inhibitor for the Treatment of Some Solid Tumors. ZLD-2 exhibited potent inhibitory activity against EZH2 and BRD4. Compared to the EZH2 inhibitor GSK126, ZLD-2 displayed potent antiproliferation activity against breast, lung, bladder, and pancreatic cancer cells. In vivo, ZLD-2 exhibited antitumor activity in a BxPC-3 mouse xenograft model, whereas GSK126 promoted tumor growth. Thus, ZLD-2 may be a lead compound for treating solid tumors.
MedKoo Cat#: 122748
Name: ZLD-2
CAS#: N/A
Chemical Formula: C29H31N5O3
Exact Mass: 497.2400
Molecular Weight: 497.60
Elemental Analysis: C, 70.00; H, 6.28; N, 14.07; O, 9.65
The following data is based on the product molecular weight 497.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
