MedKoo Cat#: 526902 | Name: Azeloprazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azeloprazole, also known as E-3710 and Z-215, is a proton pump inhibitor potentially for treatment of gastroesophageal reflux disease (GERD).

Chemical Structure

Azeloprazole
Azeloprazole
CAS#955095-45-1 (free base)

Theoretical Analysis

MedKoo Cat#: 526902

Name: Azeloprazole

CAS#: 955095-45-1 (free base)

Chemical Formula: C22H27N3O4S

Exact Mass: 429.1722

Molecular Weight: 429.54

Elemental Analysis: C, 61.52; H, 6.34; N, 9.78; O, 14.90; S, 7.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
E-3710; E 3710; E3710; Z-215; Z 215; Z215; Azeloprazole
IUPAC/Chemical Name
(R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole
InChi Key
DWDKHTXMLSZGDL-SSEXGKCCSA-N
InChi Code
InChI=1S/C22H27N3O4S/c1-14-9-23-19(13-30(26)21-24-17-7-5-6-8-18(17)25-21)15(2)20(14)27-10-16-11-28-22(3,4)29-12-16/h5-9,16H,10-13H2,1-4H3,(H,24,25)/t30-/m1/s1
SMILES Code
O=[S@@](C1=NC2=CC=CC=C2N1)CC3=NC=C(C)C(OCC4COC(C)(C)OC4)=C3C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 955095-45-1 (E-3710 free) 955095-47-3 (E-3710 sodium salt)

Preparing Stock Solutions

The following data is based on the product molecular weight 429.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kodama K, Fujisaki H, Kubota A, Kato H, Hirota K, Kuramochi H, Murota M, Tabata Y, Ueda M, Harada H, Kawahara T, Shinoda M, Watanabe N, Iida D, Terauchi H, Yasui S, Miyazawa S, Nagakawa J. E3710, a new proton pump inhibitor, with a long-lasting inhibitory effect on gastric acid secretion. J Pharmacol Exp Ther. 2010 Aug;334(2):395-401. doi: 10.1124/jpet.110.167783. Epub 2010 May 19. PubMed PMID: 20484556.