Hexapeptide-10 | CAS#146439-94-3 | peptide

MedKoo Cat#: 598108 | Name: Hexapeptide-10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hexapeptide-10 is a synthetic peptide containing Alanine, Isoleucine, Lysine, Serine and Valine residues. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities.

Chemical Structure

Hexapeptide-10

CAS#146439-94-3

Theoretical Analysis

MedKoo Cat#: 598108

Name: Hexapeptide-10

CAS#: 146439-94-3

Chemical Formula: C28H53N7O8

Exact Mass: 615.3956

Molecular Weight: 615.77

Elemental Analysis: C, 54.62; H, 8.68; N, 15.92; O, 20.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hexapeptide-10; Hexapeptide 10; Serilesine;

IUPAC/Chemical Name

L-seryl-L-isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine

InChi Key

OFGVZFQUFJYSGS-CPDXTSBQSA-N

InChi Code

InChI=1S/C28H53N7O8/c1-8-16(6)22(35-24(38)18(30)13-36)27(41)32-19(11-9-10-12-29)25(39)33-20(14(2)3)26(40)31-17(7)23(37)34-21(15(4)5)28(42)43/h14-22,36H,8-13,29-30H2,1-7H3,(H,31,40)(H,32,41)(H,33,39)(H,34,37)(H,35,38)(H,42,43)/t16-,17-,18-,19-,20-,21-,22-/m0/s1

SMILES Code

CC(C)[C@@H](C(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CO)N)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 615.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif. Oncotarget. 2015 Dec 15;6(40):42838-53. doi: 10.18632/oncotarget.5814. PubMed PMID: 26536658; PubMed Central PMCID: PMC4767475. 5: Biswas A, Kurkute P, Saleem S, Jana B, Mohapatra S, Mondal P, Adak A, Ghosh S, Saha A, Bhunia D, Biswas SC, Ghosh S. Novel hexapeptide interacts with tubulin and microtubules, inhibits Aβ fibrillation, and shows significant neuroprotection. ACS Chem Neurosci. 2015 Aug 19;6(8):1309-16. doi: 10.1021/acschemneuro.5b00149. Epub 2015 Jul 9. PubMed PMID: 26147391. 6: Yoshida M, Sekioka N, Izumikawa M, Kozone I, Takagi M, Shin-Ya K, Doi T. Total synthesis and structure elucidation of JBIR-39: a linear hexapeptide possessing piperazic acid and γ-hydroxypiperazic acid residues. Chemistry. 2015 Feb 9;21(7):3031-41. doi: 10.1002/chem.201406020. Epub 2014 Dec 18. PubMed PMID: 25524716. 7: Lin WJ, Kao LT. Cytotoxic enhancement of hexapeptide-conjugated micelles in EGFR high-expressed cancer cells. Expert Opin Drug Deliv. 2014 Oct;11(10):1537-50. doi: 10.1517/17425247.2014.930433. Epub 2014 Jun 20. PubMed PMID: 24950257. 8: Borrelli A, Schiattarella A, Mancini R, Pica A, Pollio ML, Ruggiero MG, Bonelli P, De Luca V, Tuccillo FM, Capasso C, Gori E, Sanseverino M, Carpentieri A, Birolo L, Pucci P, Rommelaere J, Mancini A. A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules. Sci Rep. 2016 Jan 4;6:18691. doi: 10.1038/srep18691. PubMed PMID: 26725847; PubMed Central PMCID: PMC4698655. 9: Takayama K, Mori K, Sohma Y, Taketa K, Taguchi A, Yakushiji F, Minamino N, Miyazato M, Kangawa K, Hayashi Y. Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites. ACS Med Chem Lett. 2015 Jan 28;6(3):302-7. doi: 10.1021/ml500494j. eCollection 2015 Mar 12. PubMed PMID: 25815150; PubMed Central PMCID: PMC4360155. 10: dos Santos GP, da Silva BF, Garrido SS, Mascini M, Yamanaka H. Design, synthesis and characterization of a hexapeptide bio-inspired by acetylcholinesterase and its interaction with pesticide dichlorvos. Analyst. 2014 Jan 7;139(1):273-9. doi: 10.1039/c3an01498c. Epub 2013 Nov 13. PubMed PMID: 24223422. 11: Niggemann J, Bozko P, Bruns N, Wodtke A, Gieseler MT, Thomas K, Jahns C, Nimtz M, Reupke I, Brüser T, Auling G, Malek N, Kalesse M. Baceridin, a cyclic hexapeptide from an epiphytic bacillus strain, inhibits the proteasome. Chembiochem. 2014 May 5;15(7):1021-9. doi: 10.1002/cbic.201300778. Epub 2014 Apr 1. PubMed PMID: 24692199. 12: Scheinpflug K, Krylova O, Nikolenko H, Thurm C, Dathe M. Evidence for a novel mechanism of antimicrobial action of a cyclic R-,W-rich hexapeptide. PLoS One. 2015 Apr 15;10(4):e0125056. doi: 10.1371/journal.pone.0125056. eCollection 2015. PubMed PMID: 25875357; PubMed Central PMCID: PMC4398456. 13: Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x. PubMed PMID: 18498523. 14: Qiao Y, Zhang M, Liang Y, Zheng J, Liang G. A computational study of self-assembled hexapeptide inhibitors against amyloid-β (Aβ) aggregation. Phys Chem Chem Phys. 2016 Dec 21;19(1):155-166. doi: 10.1039/c6cp07341g. PubMed PMID: 27929168. 15: Olejnik A, Nowak I, Eitner K, Schroeder G. Determination of Hexapeptide ALA-ASP-LEU-LYS-PRO-THR by MALDI MS. Int J Pept Res Ther. 2013;19:217-224. Epub 2012 Nov 25. PubMed PMID: 23926447; PubMed Central PMCID: PMC3726931. 16: Lamping M, Grell Y, Geyer A. Synthesis and conformational analysis of an expanded cyclic ketoxime-hexapeptide. J Pept Sci. 2016 Apr;22(4):228-35. doi: 10.1002/psc.2873. PubMed PMID: 27028207. 17: Schmartz PC, Zerbe K, Abou-Hadeed K, Robinson JA. Bis-chlorination of a hexapeptide-PCP conjugate by the halogenase involved in vancomycin biosynthesis. Org Biomol Chem. 2014 Aug 14;12(30):5574-7. doi: 10.1039/c4ob00474d. Epub 2014 Apr 23. PubMed PMID: 24756572. 18: Lungu C, Considine E, Zahir S, Ponsati B, Arrastia S, Hallett M. Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy. Eur J Neurol. 2013 Mar;20(3):515-8. doi: 10.1111/ene.12009. Epub 2012 Nov 12. PubMed PMID: 23146065; PubMed Central PMCID: PMC4747634. 19: Lara C, Reynolds NP, Berryman JT, Xu A, Zhang A, Mezzenga R. ILQINS hexapeptide, identified in lysozyme left-handed helical ribbons and nanotubes, forms right-handed helical ribbons and crystals. J Am Chem Soc. 2014 Mar 26;136(12):4732-9. doi: 10.1021/ja500445z. Epub 2014 Mar 14. PubMed PMID: 24580564. 20: Bianchi A, Giorgi C, Ruzza P, Toniolo C, Milner-White EJ. A synthetic hexapeptide designed to resemble a proteinaceous P-loop nest is shown to bind inorganic phosphate. Proteins. 2012 May;80(5):1418-24. doi: 10.1002/prot.24038. Epub 2012 Mar 1. PubMed PMID: 22275093.