GJ-103 sodium | CAS#1459687-96-7 | Analog of the read-through compound GJ072

MedKoo Cat#: 530574 | Name: GJ-103 sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GJ103 sodium salt is an active analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.

Chemical Structure

GJ-103 sodium

CAS#1459687-96-7 (sodium)

Theoretical Analysis

MedKoo Cat#: 530574

Name: GJ-103 sodium

CAS#: 1459687-96-7 (sodium)

Chemical Formula: C16H13N4NaO3S

Exact Mass: 0.0000

Molecular Weight: 364.35

Elemental Analysis: C, 52.74; H, 3.60; N, 15.38; Na, 6.31; O, 13.17; S, 8.80

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,450.00	2 Weeks
1g	USD 3,950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

1459687-96-7 (sodium) 1459687-89-8 (free acid)

Synonym

GJ-103 sodium; GJ103; GJ 103; GJ-103

IUPAC/Chemical Name

sodium 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate

InChi Key

PTFQBXAUOWUATD-UHFFFAOYSA-M

InChi Code

InChI=1S/C16H14N4O3S.Na/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22;/h2-9H,10H2,1H3,(H,21,22);/q;+1/p-1

SMILES Code

O=C([O-])CSC1=NN=C(C2=NC=CC=C2)N1C3=CC=CC(OC)=C3.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GJ103 sodium salt is an active analog of the read-through compound GJ072.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	82.34
	DMSO	40.0	109.78
	DMSO:PBS (pH 7.2) (1:2)	0.3	0.91

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 364.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. doi: 10.1038/mt.2013.150. Epub 2013 Jun 18. PubMed PMID: 23774824; PubMed Central PMCID: PMC3776636. 2: Lavin MF. Generating SM(a)RTer compounds for translation termination suppression in A-T and other genetic disorders. Mol Ther. 2013 Sep;21(9):1650-2. doi: 10.1038/mt.2013.177. PubMed PMID: 24008619; PubMed Central PMCID: PMC3776641.