MedKoo Cat#: 530575 | Name: GJ-103 free acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GJ-103 is an active analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.

Chemical Structure

GJ-103 free acid
GJ-103 free acid
CAS#1459687-89-8 (free acid)

Theoretical Analysis

MedKoo Cat#: 530575

Name: GJ-103 free acid

CAS#: 1459687-89-8 (free acid)

Chemical Formula: C16H14N4O3S

Exact Mass: 342.0787

Molecular Weight: 342.37

Elemental Analysis: C, 56.13; H, 4.12; N, 16.36; O, 14.02; S, 9.36

Price and Availability

Size Price Availability Quantity
100mg USD 750.00 2 Weeks
200mg USD 1,150.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 4,650.00 2 Weeks
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Synonym
GJ-103 free acid; GJ103; GJ 103; GJ-103.
IUPAC/Chemical Name
2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid
InChi Key
GBVQSAZHPCDBDY-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N4O3S/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22/h2-9H,10H2,1H3,(H,21,22)
SMILES Code
O=C(O)CSC1=NN=C(C2=NC=CC=C2)N1C3=CC=CC(OC)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
GJ-103 is an active analog of the read-through compound GJ072.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 342.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. doi: 10.1038/mt.2013.150. Epub 2013 Jun 18. PubMed PMID: 23774824; PubMed Central PMCID: PMC3776636. 2: Lavin MF. Generating SM(a)RTer compounds for translation termination suppression in A-T and other genetic disorders. Mol Ther. 2013 Sep;21(9):1650-2. doi: 10.1038/mt.2013.177. PubMed PMID: 24008619; PubMed Central PMCID: PMC3776641.