Cgp 44099 | CAS#128856-81-5 | renin inhibitor

MedKoo Cat#: 598053 | Name: Cgp 44099

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cgp 44099 is a potent inhibitor of plasma renin from all subprimate species.

Chemical Structure

Cgp 44099

CAS#128856-81-5

Theoretical Analysis

MedKoo Cat#: 598053

Name: Cgp 44099

CAS#: 128856-81-5

Chemical Formula: C69H104N14O13

Exact Mass: 1336.7907

Molecular Weight: 1337.67

Elemental Analysis: C, 61.96; H, 7.84; N, 14.66; O, 15.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Cgp 44099; Cgp-44099; Cgp44099;

IUPAC/Chemical Name

methyl ((2S,4S,5S)-5-((S)-2-((S)-2-((S)-1-(((benzyloxy)carbonyl)-L-arginyl-L-arginyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-3-methylbutanamido)-6-cyclohexyl-4-hydroxy-2-isopropylhexanoyl)-L-valyl-L-tyrosinate

InChi Key

YUXPQHJPUCVLDD-CSXZFWIZSA-N

InChi Code

InChI=1S/C69H104N14O13/c1-41(2)49(59(86)81-57(42(3)4)64(91)79-54(66(93)95-7)38-46-29-31-48(84)32-30-46)39-56(85)52(36-44-20-11-8-12-21-44)77-63(90)58(43(5)6)82-61(88)53(37-45-22-13-9-14-23-45)78-62(89)55-28-19-35-83(55)65(92)51(27-18-34-75-68(72)73)76-60(87)50(26-17-33-74-67(70)71)80-69(94)96-40-47-24-15-10-16-25-47/h9-10,13-16,22-25,29-32,41-44,49-58,84-85H,8,11-12,17-21,26-28,33-40H2,1-7H3,(H,76,87)(H,77,90)(H,78,89)(H,79,91)(H,80,94)(H,81,86)(H,82,88)(H4,70,71,74)(H4,72,73,75)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-/m0/s1

SMILES Code

O=C(OCc1ccccc1)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N(CCC2)[C@@H]2C(N[C@@H](Cc3ccccc3)C(N[C@@H](C(C)C)C(N[C@@H](CC4CCCCC4)[C@@H](O)C[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](Cc5ccc(O)cc5)C(OC)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,337.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wood JM, Mah SC, Baum HP, de Gasparo M, Cumin F, Rüeger H, Nussberger J. Evaluation of a potent inhibitor of subprimate and primate renins. J Pharmacol Exp Ther. 1990 May;253(2):513-7. PubMed PMID: 2110974. 2: Fleetwood G, Boutinet S, Meier M, Wood JM. Involvement of the renin-angiotensin system in ischemic damage and reperfusion arrhythmias in the isolated perfused rat heart. J Cardiovasc Pharmacol. 1991 Mar;17(3):351-6. PubMed PMID: 1711594. 3: Wood JM, Mah SC, Schnell C. Comparison of the acute hypotensive effects of renin inhibition, converting enzyme inhibition, and angiotensin II antagonism in rats. J Cardiovasc Pharmacol. 1990;16 Suppl 4:S60-4. PubMed PMID: 1705630.