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MedKoo Cat#: 573736 | Name: Alcuronium free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alcuronium free base is a non-depolarizing skeletal muscle relaxant similar to Tubocurarine. It is used as an anesthesia adjuvant.

Chemical Structure

Alcuronium free base
Alcuronium free base
CAS#23214-96-2

Theoretical Analysis

MedKoo Cat#: 573736

Name: Alcuronium free base

CAS#: 23214-96-2

Chemical Formula: C44H50N4O22

Exact Mass: 666.3923

Molecular Weight: 666.91

Elemental Analysis: C, 79.24; H, 7.56; N, 8.40; O, 4.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
15180-03-7 (chloride)
Synonym
Alcuronium, Alcuronium kation, Alcuronium free base, Alcuronum, Alloferine, Diallylnortoxiferine, Diallyltoxiferine
IUPAC/Chemical Name
4,4'-Didemethyl-4,4'-di-2-propenyl-toxiferine I (9CI)
InChi Key
MUQUYTSLDVKIOF-CHJKCJHBSA-N
InChi Code
1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-/m0/s1
SMILES Code
OC\C=C/1\C[N@+]2(CC=C)CC[C@@]34[C@@H]2C[C@@H]1\C\5=C\N6[C@H]7\C(=C/N([C@H]35)c8ccccc48)\[C@H]9C[C@H]%10[C@@]7(CC[N@@+]%10(CC=C)C/C/9=C/CO)c%11ccccc6%11
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 666.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zahn K, Eckstein N, Tränkle C, Sadée W, Mohr K. Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist. J Pharmacol Exp Ther. 2002 May;301(2):720-8. PubMed PMID: 11961078. 2: Jakubík J, Bacáková L, el-Fakahany EE, Tucek S. Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors. J Pharmacol Exp Ther. 1995 Sep;274(3):1077-83. PubMed PMID: 7562472. 3: Jakubík J, Tucek S. Protection by alcuronium of muscarinic receptors against chemical inactivation and location of the allosteric binding site for alcuronium. J Neurochem. 1994 Nov;63(5):1932-40. PubMed PMID: 7931349. 4: Proska J, Tucek S. Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors. Mol Pharmacol. 1994 Apr;45(4):709-17. PubMed PMID: 8183250. 5: Walker J, Shanks CA, Triggs EJ. Clinical pharmacokinetics of alcuronium chloride in man. Eur J Clin Pharmacol. 1980 Jun;17(6):449-57. PubMed PMID: 7398736. 6: Jones RS, Heckmann R, Wuersch W. Observations on the neuromuscular blocking action of alcuronium in the dog and its reversal by neostigmine. Res Vet Sci. 1978 Jul;25(1):101-2. PubMed PMID: 212797.