MedKoo Cat#: 412731 | Name: CGP7040

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP7040 is a rifamycin analogue, is a protein 50S ribosomal subunit inhibitor that was being developed by Novartis.

Chemical Structure

CGP7040
CGP7040
CAS#122188-44-7

Theoretical Analysis

MedKoo Cat#: 412731

Name: CGP7040

CAS#: 122188-44-7

Chemical Formula: C51H67N3O12

Exact Mass: 913.4725

Molecular Weight: 914.11

Elemental Analysis: C, 67.01; H, 7.39; N, 4.60; O, 21.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
CGP7040; CGP 7040; CGP-7040;
IUPAC/Chemical Name
3-(2,4,6-Trimethylbenzylpiperazinyl)rifamycin SV
InChi Key
ILHGDLYAJLWSGO-YAAICTFBSA-N
InChi Code
InChI=1S/C51H67N3O12/c1-25-22-28(4)35(29(5)23-25)24-53-17-19-54(20-18-53)41-40-45(59)38-37(46(41)60)39-48(33(9)44(38)58)66-51(11,49(39)61)64-21-16-36(63-12)30(6)47(65-34(10)55)32(8)43(57)31(7)42(56)26(2)14-13-15-27(3)50(62)52-40/h13-16,21-23,26,30-32,36,42-43,47,56-60H,17-20,24H2,1-12H3,(H,52,62)/b14-13+,21-16+,27-15-/t26-,30+,31+,32-,36-,42-,43-,47+,51-/m0/s1
SMILES Code
CO[C@H]1/C=C/O[C@@]2(C)OC3=C(C(O)=C(C(O)=C(C(N4CCN(CC5=C(C)C=C(C)C=C5C)CC4)=C6O)NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@H](OC(C)=O)[C@@H]1C)=O)C6=C3C2=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 914.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dickinson JM, Mitchison DA. In vitro activity of new rifamycins against rifampicin-resistant M. tuberculosis and MAIS-complex mycobacteria. Tubercle. 1987 Sep;68(3):177-82. doi: 10.1016/0041-3879(87)90053-5. PMID: 2834842. 2: Heifets LB, Lindholm-Levy PJ, Flory MA. Bactericidal activity in vitro of various rifamycins against Mycobacterium avium and Mycobacterium tuberculosis. Am Rev Respir Dis. 1990 Mar;141(3):626-30. doi: 10.1164/ajrccm/141.3.626. PMID: 2155555. 3: Kawahara S. [Chemotherapeutic agents under study]. Nihon Rinsho. 1998 Dec;56(12):3096-9. Japanese. PMID: 9883617. 4: Amitani R, Kuze F. [New drugs against tuberculosis and nontuberculous mycobacterial infections: a review]. Kekkaku. 1994 Nov;69(11):711-7. Japanese. PMID: 7837725. 5: Klemens SP, Cynamon MH. In vivo activities of newer rifamycin analogs against Mycobacterium avium infection. Antimicrob Agents Chemother. 1991 Oct;35(10):2026-30. doi: 10.1128/aac.35.10.2026. PMID: 1662021; PMCID: PMC245319. 6: Dickinson JM, Mitchison DA. In vitro observations on the suitability of new rifamycins for the intermittent chemotherapy of tuberculosis. Tubercle. 1987 Sep;68(3):183-93. doi: 10.1016/0041-3879(87)90054-7. PMID: 2834843. 7: Pedroso de Lima MC, Chiche BH, Debs RJ, Düzgüneş N. Interaction of antimycobacterial and anti-pneumocystis drugs with phospholipid membranes. Chem Phys Lipids. 1990 Mar;53(4):361-71. doi: 10.1016/0009-3084(90)90034-o. PMID: 2160335.