MedKoo Cat#: 598005 | Name: Benzotript

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzotript is an anti-gastrinic.

Chemical Structure

Benzotript
CAS#39544-74-6

Theoretical Analysis

MedKoo Cat#: 598005

Name: Benzotript

CAS#: 39544-74-6

Chemical Formula: C18H15ClN2O3

Exact Mass: 342.0771

Molecular Weight: 342.77

Elemental Analysis: C, 63.07; H, 4.41; Cl, 10.34; N, 8.17; O, 14.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Benzotript; Benzotriptum;
IUPAC/Chemical Name
(4-chlorobenzoyl)-L-tryptophan
InChi Key
QJERBBQXOMUURJ-INIZCTEOSA-N
InChi Code
InChI=1S/C18H15ClN2O3/c19-13-7-5-11(6-8-13)17(22)21-16(18(23)24)9-12-10-20-15-4-2-1-3-14(12)15/h1-8,10,16,20H,9H2,(H,21,22)(H,23,24)/t16-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(Cl)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gaudreau P, Lavigne GJ, Quirion R. Cholecystokinin antagonists proglumide, lorglumide and benzotript, but not L-364,718, interact with brain opioid binding sites. Neuropeptides. 1990 May;16(1):51-5. PubMed PMID: 2174522. 2: Hahne WF, Jensen RT, Lemp GF, Gardner JD. Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6304-8. PubMed PMID: 6171817; PubMed Central PMCID: PMC349027. 3: Magous R, Bali JP. Evidence that proglumide and benzotript antagonize secretagogue stimulation of isolated gastric parietal cells. Regul Pept. 1983 Nov;7(3):233-41. PubMed PMID: 6320314. 4: Niederau C, Ferrell LD, Grendell JH. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology. 1985 May;88(5 Pt 1):1192-204. PubMed PMID: 2984080. 5: Rorison KA, Yang Z, Baldwin GS. Affinity of cholecystokinin receptor antagonists for the gastrin-binding protein. Eur J Pharmacol. 2000 Jan 24;388(1):9-15. PubMed PMID: 10657541. 6: Hoosein NM, Kiener PA, Curry RC, Rovati LC, McGilbra DK, Brattain MG. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res. 1988 Dec 15;48(24 Pt 1):7179-83. PubMed PMID: 3191491. 7: Miazza BM, Turberg Y, Guillaume P, Hahne W, Chayvialle JA, Loizeau E. Mechanism of pancreatic growth induced by pancreatico-biliary diversion in the rat. Inhibition by proglumide, benzotript, and ranitidine. Scand J Gastroenterol Suppl. 1985;112:75-83. PubMed PMID: 2409583. 8: Panerai AE, Rovati LC, Cocco E, Sacerdote P, Mantegazza P. Dissociation of tolerance and dependence to morphine: a possible role for cholecystokinin. Brain Res. 1987 Apr 28;410(1):52-60. PubMed PMID: 3580899. 9: Crawley JN, Stivers JA, Hommer DW, Skirboll LR, Paul SM. Antagonists of central and peripheral behavioral actions of cholecystokinin octapeptide. J Pharmacol Exp Ther. 1986 Feb;236(2):320-30. PubMed PMID: 3003339. 10: Hashimoto T, Shindo Y, Souri M, Baldwin GS. A new inhibitor of mitochondrial fatty acid oxidation. J Biochem. 1996 Jun;119(6):1196-201. PubMed PMID: 8827458. 11: Kerwin JF Jr, Wagenaar F, Kopecka H, Lin CW, Miller T, Witte D, Stashko M, Nadzan AM. Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. J Med Chem. 1991 Dec;34(12):3350-9. PubMed PMID: 1766000. 12: Murphy VJ, Mantamadiotis T, Baldwin GS. Gastrin and gastrin receptor antagonists bind to both N- and C-terminal halves of the 78 kDa gastrin-binding protein. Int J Biochem Cell Biol. 1996 Nov;28(11):1233-40. PubMed PMID: 9022282. 13: Gupta AK, Varshney K, Singh N, Mishra V, Saxena M, Palit G, Saxena AK. Identification of novel amino acid derived CCK-2R antagonists as potential antiulcer agent: homology modeling, design, synthesis, and pharmacology. J Chem Inf Model. 2013 Jan 28;53(1):176-87. doi: 10.1021/ci3003655. Epub 2013 Jan 4. PubMed PMID: 23240656. 14: Saxena AK, Pandey SK, Tripathi RC, Raghubir R. Synthesis, molecular modeling and QSAR studies in chiral 2,3-disubstituted-1,2,3,4-tetrahydro-9H-pyrido(3,4-b)indoles as potential modulators of opioid antinociception. Bioorg Med Chem. 2001 Jun;9(6):1559-70. PubMed PMID: 11408175. 15: Magous R, Martinez J, Lignon MF, Nisato D, Castro B, Bali JP. Abilities of some tryptophan and phenylalanine derivatives to inhibit gastric acid secretion. Biochim Biophys Acta. 1985 May 30;845(2):158-62. PubMed PMID: 2986716. 16: Blackmore M, Doherty E, Manning JE, Hirst BH. Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide. Int J Cancer. 1994 May 1;57(3):385-91. PubMed PMID: 8169000. 17: Sinton CM. Cholecystokinin modulates neurotransmission through the dentate gyrus. Neurosci Lett. 1988 Dec 19;95(1-3):341-6. PubMed PMID: 2852324. 18: Baldwin GS. Inhibition of the preferential binding of actin to the N-terminal hydratase domain of the 78-kDa gastrin-binding protein by non-steroidal anti-inflammatory drugs and gastrin receptor antagonists. Biochem Pharmacol. 2001 May 1;61(9):1129-36. PubMed PMID: 11301046. 19: Westfall S, Andrus C, Schlarman D, Kaminski DL. The effect of cholecystokinin-receptor antagonists on cholecystokinin-stimulated bile flow in dogs. Surgery. 1991 Mar;109(3 Pt 1):294-300. PubMed PMID: 2000561. 20: Sinton CM. Cholecystokinin and cholecystokinin antagonists enhance postsynaptic excitability in the dentate gyrus. Peptides. 1988 Sep-Oct;9(5):1049-53. PubMed PMID: 3244557.