MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 597996 | Name: Rolicyprine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rolicyprine is an antidepressant.

Chemical Structure

Rolicyprine
Rolicyprine
CAS#2829-19-8

Theoretical Analysis

MedKoo Cat#: 597996

Name: Rolicyprine

CAS#: 2829-19-8

Chemical Formula: C14H16N2O2

Exact Mass: 244.1212

Molecular Weight: 244.24

Elemental Analysis: C, 68.83; H, 6.60; N, 11.47; O, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Rolicyprine; RMI 83,027; RMI-83,027; RMI83,027; RMI 83027; RMI-83027; RMI83027;
IUPAC/Chemical Name
5-oxo-N-(2-phenylcyclopropyl)pyrrolidine-2-carboxamide
InChi Key
UGSLDMJXBQKDCT-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H16N2O2/c17-13-7-6-11(15-13)14(18)16-12-8-10(12)9-4-2-1-3-5-9/h1-5,10-12H,6-8H2,(H,15,17)(H,16,18)
SMILES Code
O=C(C(CC1)NC1=O)NC2C(C3=CC=CC=C3)C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen B, Xu M, Zhang H, Xu MZ, Wang XJ, Tang QH, Tang JY. The Antipancreatic Cancer Activity of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2. DNA Cell Biol. 2015 Oct;34(10):610-7. doi: 10.1089/dna.2015.2886. Epub 2015 Aug 18. PubMed PMID: 26284306; PubMed Central PMCID: PMC4593879. 2: Cassir N, Delarozière JC, Dubourg G, Delord M, Lagier JC, Brouqui P, Fenollar F, Raoult D, Fournier PE. A Regional Outbreak of Clostridium difficile PCR-Ribotype 027 Infections in Southeastern France from a Single Long-Term Care Facility. Infect Control Hosp Epidemiol. 2016 Nov;37(11):1337-1341. Epub 2016 Aug 3. PubMed PMID: 27484769. 3: Mentula S, Laakso S, Lyytikäinen O, Kirveskari J. Differentiating virulent 027 and non-027 Clostridium difficile strains by molecular methods. Expert Rev Mol Diagn. 2015;15(9):1225-9. doi: 10.1586/14737159.2015.1069710. Epub 2015 Aug 4. PubMed PMID: 26289601. 4: Kamboj M, Xiao K, Kaltsas A, Huang YT, Sun J, Chung D, Wu S, Sheahan A, Sepkowitz K, Jakubowski AA, Papanicolaou G. Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. Biol Blood Marrow Transplant. 2014 Oct;20(10):1626-33. doi: 10.1016/j.bbmt.2014.06.025. Epub 2014 Jun 25. PubMed PMID: 24973628; PubMed Central PMCID: PMC4852556. 5: Zhi X, Chen W, Xue F, Liang C, Chen BW, Zhou Y, Wen L, Hu L, Shen J, Bai X, Liang T. OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo. Oncotarget. 2015 Sep 22;6(28):26230-41. doi: 10.18632/oncotarget.4579. PubMed PMID: 26213847; PubMed Central PMCID: PMC4694897. 6: Camacho-Ortiz A, López-Barrera D, Hernández-García R, Galván-De Los Santos AM, Flores-Treviño SM, Llaca-Díaz JM, Maldonado-Garza HJ, Bosques-Padilla FJ, Garza-González E. First report of Clostridium difficile NAP1/027 in a Mexican hospital. PLoS One. 2015 Apr 27;10(4):e0122627. doi: 10.1371/journal.pone.0122627. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0129079. Garza, Héctor J Maldonado [corrected to Maldonado-Garza, Héctor J]. PubMed PMID: 25915544; PubMed Central PMCID: PMC4411131. 7: Arvand M, Vollandt D, Bettge-Weller G, Harmanus C, Kuijper EJ; Clostridium difficile study group Hesse. Increased incidence of Clostridium difficile PCR ribotype 027 in Hesse, Germany, 2011 to 2013. Euro Surveill. 2014 Mar 13;19(10). pii: 20732. PubMed PMID: 24650866. 8: Orlova A, Jonsson A, Rosik D, Lundqvist H, Lindborg M, Abrahmsen L, Ekblad C, Frejd FY, Tolmachev V. Site-specific radiometal labeling and improved biodistribution using ABY-027, a novel HER2-targeting affibody molecule-albumin-binding domain fusion protein. J Nucl Med. 2013 Jun;54(6):961-8. doi: 10.2967/jnumed.112.110700. Epub 2013 Mar 25. PubMed PMID: 23528382. 9: Holt HM, Danielsen TK, Justesen US. Routine disc diffusion antimicrobial susceptibility testing of Clostridium difficile and association with PCR ribotype 027. Eur J Clin Microbiol Infect Dis. 2015 Nov;34(11):2243-6. doi: 10.1007/s10096-015-2475-x. Epub 2015 Aug 30. PubMed PMID: 26319148. 10: Stabler RA, He M, Dawson L, Martin M, Valiente E, Corton C, Lawley TD, Sebaihia M, Quail MA, Rose G, Gerding DN, Gibert M, Popoff MR, Parkhill J, Dougan G, Wren BW. Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol. 2009;10(9):R102. doi: 10.1186/gb-2009-10-9-r102. Epub 2009 Sep 25. PubMed PMID: 19781061; PubMed Central PMCID: PMC2768977. 11: Robinson CD, Auchtung JM, Collins J, Britton RA. Epidemic Clostridium difficile strains demonstrate increased competitive fitness compared to nonepidemic isolates. Infect Immun. 2014 Jul;82(7):2815-25. doi: 10.1128/IAI.01524-14. Epub 2014 Apr 14. PubMed PMID: 24733099; PubMed Central PMCID: PMC4097623. 12: Morfin-Otero R, Garza-Gonzalez E, Aguirre-Diaz SA, Escobedo-Sanchez R, Esparza-Ahumada S, Perez-Gomez HR, Petersen-Morfin S, Gonzalez-Diaz E, Martinez-Melendez A, Rodriguez-Noriega E; Hospital Civil de Guadalajara, Fray Antonio Alcalde Clostridium difficile Team. Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital. Braz J Infect Dis. 2016 Jan-Feb;20(1):8-13. doi: 10.1016/j.bjid.2015.09.008. Epub 2015 Nov 24. PubMed PMID: 26620948. 13: Boone JH, Archbald-Pannone LR, Wickham KN, Carman RJ, Guerrant RL, Franck CT, Lyerly DM. Ribotype 027 Clostridium difficile infections with measurable stool toxin have increased lactoferrin and are associated with a higher mortality. Eur J Clin Microbiol Infect Dis. 2014 Jun;33(6):1045-51. doi: 10.1007/s10096-013-2043-1. Epub 2014 Jan 22. PubMed PMID: 24449345; PubMed Central PMCID: PMC4013447. 14: Cheng JW, Xiao M, Kudinha T, Xu ZP, Hou X, Sun LY, Zhang L, Fan X, Kong F, Xu YC. The First Two Clostridium difficile Ribotype 027/ST1 Isolates Identified in Beijing, China-an Emerging Problem or a Neglected Threat? Sci Rep. 2016 Jan 7;6:18834. doi: 10.1038/srep18834. PubMed PMID: 26740150; PubMed Central PMCID: PMC4703979. 15: Reigadas E, Alcalá L, Marín M, Martín A, Iglesias C, Bouza E. Role of binary toxin in the outcome of Clostridium difficile infection in a non-027 ribotype setting. Epidemiol Infect. 2016 Jan;144(2):268-73. doi: 10.1017/S095026881500148X. Epub 2015 Jun 29. Erratum in: Epidemiol Infect. 2016 Sep;144(12):2691. PubMed PMID: 26119775. 16: Kansau I, Barketi-Klai A, Monot M, Hoys S, Dupuy B, Janoir C, Collignon A. Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis. PLoS One. 2016 Jun 28;11(6):e0158204. doi: 10.1371/journal.pone.0158204. eCollection 2016. PubMed PMID: 27351947; PubMed Central PMCID: PMC4924792. 17: Arvand M, Bettge-Weller G. Clostridium difficile ribotype 027 is not evenly distributed in Hesse, Germany. Anaerobe. 2016 Aug;40:1-4. doi: 10.1016/j.anaerobe.2016.04.006. Epub 2016 Apr 7. PubMed PMID: 27063988. 18: Grando D, Said MM, Mayall BC, Gurtler V. High resolution melt analysis to track infections due to ribotype 027 Clostridium difficile. J Microbiol Methods. 2012 May;89(2):87-94. doi: 10.1016/j.mimet.2012.02.011. Epub 2012 Mar 3. PubMed PMID: 22406296. 19: Lachowicz D, Szulencka G, Obuch-Woszczatyński P, van Belkum A, Pituch H. First Polish outbreak of Clostridium difficile ribotype 027 infections among dialysis patients. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):63-67. doi: 10.1007/s10096-014-2204-x. Epub 2014 Jul 26. PubMed PMID: 25060801; PubMed Central PMCID: PMC4281364. 20: Mascart G, Delmée M, Van Broeck J, Cytryn E, Karmali R, Cherifi S. Impact of ribotype 027 on Clostridium difficile infection in a geriatric department. Eur J Clin Microbiol Infect Dis. 2013 Sep;32(9):1177-82. doi: 10.1007/s10096-013-1864-2. Epub 2013 Apr 5. PubMed PMID: 23558363.