MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 592253 | Name: Peryllartine
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Peryllartine is a sweetener that is about 2000 times as sweet as sucrose. Perillartine is the oxime of perillaldehyde.

Chemical Structure

Peryllartine
CAS# 30950-27-7

Theoretical Analysis

MedKoo Cat#: 592253

Name: Peryllartine

CAS#: 30950-27-7

Chemical Formula: C10H15NO

Exact Mass: 165.1154

Molecular Weight: 165.24

Elemental Analysis: C, 72.69; H, 9.15; N, 8.48; O, 9.68

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
5g USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Peryllartine; AI3-52127; AI3 52127; AI352127, Perilla sugar, Perillartine
IUPAC/Chemical Name
(E)-4-(1-Methylvinyl)cyclohexene-1-carbaldehyde oxime
InChi Key
XCOJIVIDDFTHGB-YRNVUSSQSA-N
InChi Code
InChI=1S/C10H15NO/c1-8(2)10-5-3-9(4-6-10)7-11-12/h3,7,10,12H,1,4-6H2,2H3/b11-7+
SMILES Code
C=C(C1CC=C(/C=N/O)CC1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.
In vitro activity:
In the search for drugs to treat liver steatosis, this study screened 303 natural products using HepG2 cells and discovered that perillartine derived from Perilla frutescens (L.) improved fat deposition as well as glucose homeostasis in hepatocytes. In vitro, perillartine reduced the expression of genes involved in lipid synthesis, lipid transport, and gluconeogenesis in hepatocytes, increased the number of mitochondria, and upregulated the phosphorylation of Akt. Reference: Food Funct. 2023 Jan 23;14(2):961-977. https://pubmed.ncbi.nlm.nih.gov/36541423/
In vivo activity:
This study explored the effects of perillartine on lipid metabolism in broiler chickens by establishing a nonalcoholic fatty liver model induced by a high-fat diet. By using network pharmacology and molecular docking, this study analyzed the potential molecular targets and pathways through which perillartine regulates lipid metabolism and alleviates fatty liver. Perillartine was found to regulate the expression of genes associated with lipogenesis, lipolysis, and lipid transport, including FASN, PPARα, CPT-1, ACCα, APOB, and APOA1 in the liver, and to decrease lipid accumulation in the liver and blood in broilers without affecting growth performance. In addition, we discovered 24 candidate targets of perillartine, including SRD5A2 and XDH, through network pharmacology analysis and successfully constructed a compound-target-pathway-disease network. Reference: Biochem Biophys Res Commun. 2022 Oct 15;625:66-74. https://pubmed.ncbi.nlm.nih.gov/35952609/
Solvent mg/mL mM comments
Solubility
DMSO 66.5 402.45
Water 0.7 4.05
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 165.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Xiao Y, Xiao L, Li M, Liu S, Wang Y, Huang L, Liu S, Jiang T, Zhou L, Li Y. Perillartine protects against metabolic associated fatty liver in high-fat diet-induced obese mice. Food Funct. 2023 Jan 23;14(2):961-977. doi: 10.1039/d2fo02227c. PMID: 36541423. 2. Xiao Y, Jia M, Jiang T, Zhang C, Qi X, Sun Y, Gao J, Zhou L, Li Y. Dietary supplementation with perillartine ameliorates lipid metabolism disorder induced by a high-fat diet in broiler chickens. Biochem Biophys Res Commun. 2022 Oct 15;625:66-74. doi: 10.1016/j.bbrc.2022.07.116. Epub 2022 Aug 2. PMID: 35952609.
In vitro protocol:
1. Xiao Y, Xiao L, Li M, Liu S, Wang Y, Huang L, Liu S, Jiang T, Zhou L, Li Y. Perillartine protects against metabolic associated fatty liver in high-fat diet-induced obese mice. Food Funct. 2023 Jan 23;14(2):961-977. doi: 10.1039/d2fo02227c. PMID: 36541423.
In vivo protocol:
1. Xiao Y, Jia M, Jiang T, Zhang C, Qi X, Sun Y, Gao J, Zhou L, Li Y. Dietary supplementation with perillartine ameliorates lipid metabolism disorder induced by a high-fat diet in broiler chickens. Biochem Biophys Res Commun. 2022 Oct 15;625:66-74. doi: 10.1016/j.bbrc.2022.07.116. Epub 2022 Aug 2. PMID: 35952609.
1: Cai C, Jiang H, Li L, Liu T, Song X, Liu B. Characterization of the Sweet Taste Receptor Tas1r2 from an Old World Monkey Species Rhesus Monkey and Species-Dependent Activation of the Monomeric Receptor by an Intense Sweetener Perillartine. PLoS One. 2016 Aug 1;11(8):e0160079. doi: 10.1371/journal.pone.0160079. eCollection 2016. PubMed PMID: 27479072; PubMed Central PMCID: PMC4968786. 2: Yuan XY, Zhang M, Ng SW. Perillartine. Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 15;65(Pt 9):o2149. doi: 10.1107/S1600536809031225. PubMed PMID: 21577558; PubMed Central PMCID: PMC2969981. 3: Venanzi TJ, Venanzi CA. Ab initio molecular electrostatic potentials of perillartine analogues: implications for sweet-taste receptor recognition. J Med Chem. 1988 Oct;31(10):1879-85. PubMed PMID: 3172123.