SIS17 | CAS#2374313-54-7 | HDAC11 inhibitor

MedKoo Cat#: 555620 | Name: SIS-17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIS-17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS-17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

Chemical Structure

SIS-17

CAS#2374313-54-7

Theoretical Analysis

MedKoo Cat#: 555620

Name: SIS-17

CAS#: 2374313-54-7

Chemical Formula: C21H38N2OS

Exact Mass: 366.2705

Molecular Weight: 366.61

Elemental Analysis: C, 68.80; H, 10.45; N, 7.64; O, 4.36; S, 8.75

Price and Availability

Size	Price	Availability
10mg	USD 150.00	Ready to ship
25mg	USD 250.00	Ready to ship
50mg	USD 450.00	Ready to ship
100mg	USD 750.00	Ready to ship
200mg	USD 1,350.00	Ready to ship
500mg	USD 2,650.00	Ready to ship
1g	USD 3,850.00	Ready to ship

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Related CAS #

No Data

Synonym

SIS-17; SIS 17; SIS17;

IUPAC/Chemical Name

N'-hexadecylthiophene-2-carbohydrazide

InChi Key

HSHXDCVZWHOWCS-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)

SMILES Code

O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Mammalian histone deacetylases (HDACs) are a class of enzymes that play important roles in biological pathways. Existing HDAC inhibitors target multiple HDACs without much selectivity. Inhibitors that target one particular HDAC will be useful for investigating the biological functions of HDACs and for developing better therapeutics.

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A9T11K07

QC Data

View QC data: current batch, Lot#A9T11K07

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

SIS-17 is a histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM.

In vitro activity:

Results from this study indicate that SIS-17 is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Reference: ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893910/

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMSO	99.0	270.04
	Ethanol	18.0	49.10

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 366.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Li R, Wu X, Zhao P, Xue K, Li J. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36(7):e22326. doi: 10.1096/fj.202101742RR. PMID: 35657209. 2. Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. doi: 10.1021/acschembio.9b00292. Epub 2019 Jul 2. PMID: 31264832; PMCID: PMC6893910. In vivo study To be determined

In vitro protocol:

In vivo protocol:

To be determined

1: Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. doi: 10.1021/acschembio.9b00292. Epub 2019 Jul 2. PubMed PMID: 31264832.