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MedKoo Cat#: 597888 | Name: Enalapril sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Enalapril sodium is a medication used to treat high blood pressure, diabetic kidney disease, and heart failure. For heart failure it is generally used with a diuretic such as furosemide.

Chemical Structure

Enalapril sodium
Enalapril sodium
CAS#149404-21-7 (sodium)

Theoretical Analysis

MedKoo Cat#: 597888

Name: Enalapril sodium

CAS#: 149404-21-7 (sodium)

Chemical Formula: C20H27N2NaO5

Exact Mass: 0.0000

Molecular Weight: 398.43

Elemental Analysis: C, 60.29; H, 6.83; N, 7.03; Na, 5.77; O, 20.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
75847-73-3 (free acid) 76095-16-4 (maleate) 149404-21-7 (sodium)
Synonym
Enalapril sodium; (-)-Enalapril sodium;
IUPAC/Chemical Name
sodium ((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-L-prolinate
InChi Key
FTTHROYWFRGKST-BDURURIASA-M
InChi Code
InChI=1S/C20H28N2O5.Na/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);/q;+1/p-1/t14-,16-,17-;/m0./s1
SMILES Code
O=C([O-])[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 398.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Spencer AG, Labonte ED, Rosenbaum DP, Plato CF, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Bell N, Tabora J, Joly KM, Navre M, Jacobs JW, Charmot D. Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans. Sci Transl Med. 2014 Mar 12;6(227):227ra36. doi: 10.1126/scitranslmed.3007790. PubMed PMID: 24622516. 2: Thomason JD, Rapoport G, Fallaw T, Calvert CA. The influence of enalapril and spironolactone on electrolyte concentrations in Doberman pinschers with dilated cardiomyopathy. Vet J. 2014 Dec;202(3):573-7. doi: 10.1016/j.tvjl.2014.09.004. Epub 2014 Sep 10. PubMed PMID: 25257351. 3: Zhang YL, Wu JY, Wang XC, Liu L. Interaction of sodium loading and enalapril on renin mRNA and renin release in hydronephrotic mice. Sheng Li Xue Bao. 2009 Jun 25;61(3):239-46. PubMed PMID: 19536436. 4: Cunha TA, Serpa RC, de Oliveira AP, Nasser LN, de Freitas LA, Taveira SF, Diniz DG, Lima EM, Marreto RN. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7. doi: 10.1208/s12249-013-0006-6. Epub 2013 Jul 30. PubMed PMID: 23897034; PubMed Central PMCID: PMC3755139. 5: Mu JY, Johansson M, Lundgren O. The effects of enalapril on the natriuretic response evoked by an oral sodium load in sodium deprived normotensive and hypertensive rats. Acta Physiol Scand. 1997 Jun;160(2):157-64. PubMed PMID: 9208042. 6: Zhang Y, Wu J, Wang X, Morgan T. Effects of enalapril and sodium depletion on the renin-angiotensin system in hydronephrotic mice. Can J Physiol Pharmacol. 2009 Jul;87(7):515-21. doi: 10.1139/y09-037. PubMed PMID: 19767874. 7: Bondarenko A, Panasiuk O, Stepanenko L, Goswami N, Sagach V. Reduced hyperpolarization of endothelial cells following high dietary Na+: effects of enalapril and tempol. Clin Exp Pharmacol Physiol. 2012 Jul;39(7):608-13. doi: 10.1111/j.1440-1681.2012.05718.x. PubMed PMID: 22540516. 8: Sánchez RA, Giménez MI, Migliorini M, Giannone C, Ramírez AJ, Weder AB. Erythrocyte sodium-lithium countertransport in non-modulating offspring and essential hypertensive individuals: response to enalapril. Hypertension. 1997 Jul;30(1 Pt 1):99-105. PubMed PMID: 9231828. 9: Herlitz H, Dahlöf B, Jonsson O, Hansson L. Relationship between change in erythrocyte sodium and antihypertensive response to enalapril. J Hum Hypertens. 1994 Nov;8(11):837-41. PubMed PMID: 7853327. 10: Guron G, Nilsson A, DiBona GF, Sundelin B, Nitescu N, Friberg P. Renal adaptation to dietary sodium restriction and loading in rats treated neonatally with enalapril. Am J Physiol. 1997 Oct;273(4 Pt 2):R1421-9. PubMed PMID: 9362308. 11: Atabak S, Taziki O, Argani H, Abolghasemi R, Zangneh HF, Rahmani L. Effects of oral enalapril and verapamil on dialysis adequacy and solute clearance in chronic ambulatory peritoneal dialysis. Saudi J Kidney Dis Transpl. 2013 Nov;24(6):1170-4. doi: 10.4103/1319-2442.121274. PubMed PMID: 24231479. 12: Polonini HC, Loures S, Lima LC, Ferreira AO, Brandão MA. Stability of Atenolol, Clonazepam, Dexamethasone, Diclofenac Sodium, Diltiazem, Enalapril Maleate, Ketoprofen, Lamotrigine, Penicillamine-D, and Thiamine in SyrSpend SF PH4 Oral Suspensions. Int J Pharm Compd. 2016 Mar-Apr;20(2):167-74. PubMed PMID: 27323429. 13: Hammouda ME, Abu El-Enin MA, El-Sherbiny DT, El-Wasseef DR, El-Ashry SM. Simultaneous determination of enalapril and hydrochlorothiazide in pharmaceutical preparations using microemulsion liquid chromatography. J Chromatogr Sci. 2015 Jan;53(1):90-6. doi: 10.1093/chromsci/bmu024. Epub 2014 Apr 25. PubMed PMID: 24771051. 14: Vos PF, Koomans HA, Boer P, Dorhout Mees EJ. Effects of angiotensin II on renal sodium handling and diluting capacity in man pretreated with high-salt diet and enalapril. Nephrol Dial Transplant. 1992;7(10):991-6. PubMed PMID: 1331894. 15: Cabral EV, Vieira-Filho LD, Silva PA, Nascimento WS, Aires RS, Oliveira FS, Luzardo R, Vieyra A, Paixão AD. Perinatal Na+ overload programs raised renal proximal Na+ transport and enalapril-sensitive alterations of Ang II signaling pathways during adulthood. PLoS One. 2012;7(8):e43791. doi: 10.1371/journal.pone.0043791. Epub 2012 Aug 22. PubMed PMID: 22928034; PubMed Central PMCID: PMC3425503. 16: Mimran A, Jover B, Dupont M. Enalapril-induced disturbance in the renal adaptation to sodium restriction in the rat. Kidney Int Suppl. 1988 Sep;25:S28-32. PubMed PMID: 2460663. 17: Vos PF, Boer P, Koomans HA. Effects of enalapril on renal sodium handling in healthy subjects on low, intermediate, and high sodium intake. J Cardiovasc Pharmacol. 1993 Jul;22(1):27-32. PubMed PMID: 7690092. 18: Visser FW, Boonstra AH, Titia Lely A, Boomsma F, Navis G. Renal response to angiotensin II is blunted in sodium-sensitive normotensive men. Am J Hypertens. 2008 Mar;21(3):323-8. doi: 10.1038/ajh.2007.63. Epub 2008 Jan 24. PubMed PMID: 18219299. 19: Buter H, Hemmelder MH, Navis G, de Jong PE, de Zeeuw D. The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide. Nephrol Dial Transplant. 1998 Jul;13(7):1682-5. PubMed PMID: 9681711. 20: Polónia J, Gama G, Santos A. [Reduction of the antihypertensive effects of enalapril by indomethacin. Its independence from renal sodium retention]. Rev Port Cardiol. 1996 Jun;15(6):485-92, 460. Portuguese. PubMed PMID: 8755685.