BW-A 575C | CAS#103221-88-1 | ACE inhibitor

MedKoo Cat#: 597866 | Name: BW-A 575C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BW-A 575C is an ACE inhibitor.

Chemical Structure

BW-A 575C

CAS#103221-88-1

Theoretical Analysis

MedKoo Cat#: 597866

Name: BW-A 575C

CAS#: 103221-88-1

Chemical Formula: C29H43N5O8

Exact Mass: 589.3112

Molecular Weight: 589.69

Elemental Analysis: C, 59.07; H, 7.35; N, 11.88; O, 21.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BW-A 575C; BW-B385C; BWB385C; BW B385C;

IUPAC/Chemical Name

(1-carboxy-5-(4-(2-hydroxy-3-(isopropylamino)propoxy)-1H-indole-2-carboxamido)pentyl)alanyl-L-proline

InChi Key

XCLLRLKRCYZTES-PBKHYBTFSA-N

InChi Code

InChI=1S/C29H43N5O8/c1-17(2)31-15-19(35)16-42-25-11-6-9-21-20(25)14-23(33-21)26(36)30-12-5-4-8-22(28(38)39)32-18(3)27(37)34-13-7-10-24(34)29(40)41/h6,9,11,14,17-19,22,24,31-33,35H,4-5,7-8,10,12-13,15-16H2,1-3H3,(H,30,36)(H,38,39)(H,40,41)/t18?,19?,22?,24-/m0/s1

SMILES Code

O=C(O)[C@H]1N(C(C(C)NC(C(O)=O)CCCCNC(C(N2)=CC3=C2C=CC=C3OCC(O)CNC(C)C)=O)=O)CCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 589.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cambridge D, Allan G, Hardy GW, Follenfant MJ, Ford A, Oliver PL. BW A575C: pharmacological profile in vivo of a novel angiotensin converting enzyme inhibitor and beta-blocker. J Cardiovasc Pharmacol. 1987;10 Suppl 11:S64-8. PubMed PMID: 2454371. 2: Cambridge D, Whiting MV, Allan G. Cardiac and renovascular effects in the anaesthetized dog of BW A575C: a novel angiotensin converting enzyme inhibitor with beta-adrenoceptor blocking properties. Br J Pharmacol. 1988 Jan;93(1):165-75. PubMed PMID: 2894874; PubMed Central PMCID: PMC1853785. 3: Cambridge D, Whiting MV, Butterfield LJ, Allan G. The effects of combined angiotensin converting enzyme inhibition and beta-adrenoceptor blockade on plasma renin activity in anaesthetized dogs. Br J Pharmacol. 1992 Jun;106(2):342-7. PubMed PMID: 1356560; PubMed Central PMCID: PMC1907514.