Hydroxydione sodium succinate | CAS# 53-10-1 | neuroactive steroid

MedKoo Cat#: 414709 | Name: Hydroxydione sodium succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxydione sodium succinate is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. It was introduced in 1957, and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.

Chemical Structure

Hydroxydione sodium succinate

CAS#53-10-1

Theoretical Analysis

MedKoo Cat#: 414709

Name: Hydroxydione sodium succinate

CAS#: 53-10-1

Chemical Formula: C25H35NaO6

Exact Mass:

Molecular Weight: 454.54

Elemental Analysis: C, 66.06; H, 7.76; Na, 5.06; O, 21.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hydroxydione sodium succinate; P55; P-55; P 55; Viadril; Presuren

IUPAC/Chemical Name

sodium 4-(2-((5R,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoate

InChi Key

BFQDICGJHAONBN-OOFWROCWSA-M

InChi Code

InChI=1S/C25H36O6.Na/c1-24-11-9-16(26)13-15(24)3-4-17-18-5-6-20(25(18,2)12-10-19(17)24)21(27)14-31-23(30)8-7-22(28)29;/h15,17-20H,3-14H2,1-2H3,(H,28,29);/q;+1/p-1/t15-,17+,18+,19+,20-,24+,25+;/m1./s1

SMILES Code

C[C@]12CCC(C[C@H]1CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@H]23)C)C(COC(CCC([O-])=O)=O)=O)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 454.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: LERMAN LH, PATON WD. Experiments on the pharmacology of hydroxydione sodium succinate. Br J Pharmacol Chemother. 1960 Sep;15(3):458-65. doi: 10.1111/j.1476-5381.1960.tb01273.x. PMID: 13761053; PMCID: PMC1481853. 2: [HYDROXYDIONE sodium succinate]. J Am Med Assoc. 1958 Sep 20;168(3):285-6. Undetermined Language. PMID: 13575157. 3: VOLLBRECHTHAUSEN F. Comentario oficial al trabajo del Sr. Dr. Adolfo Merelo Anaya intitulado "Valorización de la hidroxidiona sódica como agente inductor en anestesiología [Commentary on the article of Dr. Adolfo Merelo Anaya entitled "Evaluation of hydroxydione sodium succinate as an inductive agent in anesthesiology"]. Medicina (Mex). 1959 Apr 10;39(817):156-8. Spanish. PMID: 13656154. 4: MERELO ANAYA A. Valorización de la hidroxidiona sódica como agente inductor en en anestesiología [Evaluation of hydroxydione sodium succinate as an inductive agent in anesthesiology]. Medicina (Mex). 1959 Apr 10;39(817):152-6. Spanish. PMID: 13656153. 5: GREISHEIMER EM, ELLIS DW, STEWART GH 3rd, MAKARENKO L, OPPENHEIMER MJ. Cardiovascular functions under chloralose-urethane and 21-hydroxypregnane-3, 20-dione sodium succinate (viadril). Am J Physiol. 1957 Aug;190(2):317-9. doi: 10.1152/ajplegacy.1957.190.2.317. PMID: 13458463. 6: CLERICI LORENZINI A. [Clinical results of the use of 21-hydroxypregnane-3, 20-dione sodium succinate in gynecology]. Osp Maggiore. 1960 Sep;48:435-9. Italian. PMID: 13694071. 7: Filimonov VG, Sheveleva GA, Chesnokova IaM, Benediktova AB, Abubakirova AM. Protektivnoe deĭstvie narkoana'lgetikov na ma't, plod i potomstvo pri gipoksii [Protective effect of narcotic analgesics on the mother, fetus and offspring in hypoxia]. Akush Ginekol (Mosk). 1989 Sep;(9):52-6. Russian. PMID: 2574541. 8: SIROL J, GUILMANDIE F. ESSAI DE TRAITEMENT DU TETANOS DE L'ENFANT AFRICAIN PAR LE SUCCINATE SODIQUE DE 21-HYDROXYPREGNANDIONE. A PROPOS DE 87 CAS [ATTEMPT AT TREATMENT OF TETANUS IN THE AFRICAN CHILD WITH SODIUM SUCCINATE OF 21-HYDROXYPREGNANEDIONE]. Med Trop (Mars). 1964 Sep-Oct;24:573-9. French. PMID: 14224142. 9: RAZEMON P, LANIEZ C. Un stéroïde anesthésique: le succinate sodique de 21-hydroxyprégnandione (viadril) [Steroid anesthetic: sodium succinate of 21-hydroxypregnandione (viadril)]. Lille Chir. 1957 Jul-Oct;12(4-5):204-9. French. PMID: 13515416. 10: Mamedgasanov RM, Mazovetskiĭ AG, Semavin IE, Storozhenko LG, Rudenko GR. Osobennosti narusheniĭ v sisteme gemostaza u bol'nykh insulinnezavisimym tipom sakharnogo diabeta s angiopatiiami sosudov nizhnikh konechnosteĭ [Characteristics of disturbances in the hemostasis system in patients with insulin-dependent diabetes mellitus with angiopathies of the vessels of the lower extremities]. Ter Arkh. 1988;60(9):35-40. Russian. PMID: 3217877.