BC 197 | CAS#115295-08-4 | CCK-B agonist

MedKoo Cat#: 597743 | Name: BC 197

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BC 197 is a selective CCK-B agonist.

Chemical Structure

BC 197

CAS#115295-08-4

Theoretical Analysis

MedKoo Cat#: 597743

Name: BC 197

CAS#: 115295-08-4

Chemical Formula: C60H81N11O17S

Exact Mass: 1259.5533

Molecular Weight: 1260.42

Elemental Analysis: C, 57.18; H, 6.48; N, 12.22; O, 21.58; S, 2.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BC 197; BC-197; BC197; Boc-asp-tyr(SO3H)-ahx-lys-trp-ahx-asp-phe-NH2;

IUPAC/Chemical Name

(2S,5S,8R,11S,14S,17S,20S,24R)-11-((1H-indol-3-yl)methyl)-2-amino-8-(4-aminobutyl)-20-benzyl-5-((E)-buta-1,3-dien-1-yl)-24-((tert-butoxycarbonyl)amino)-14-butyl-1-(4-hydroxyphenyl)-3,9,12,15,18,21,23-heptaoxo-17-(2-oxo-2-(sulfooxy)ethyl)-4,7,10,13,16,19,22-heptaazahexacosan-26-oic acid

InChi Key

KUPOETRFWZHGEM-LAZFATJSSA-N

InChi Code

1S/C60H81N11O17S/c1-6-8-19-39(65-52(76)42(62)29-37-24-26-40(72)27-25-37)35-64-44(23-15-16-28-61)53(77)68-47(31-38-34-63-43-22-14-13-20-41(38)43)55(79)66-45(21-9-7-2)54(78)69-49(33-51(75)88-89(84,85)86)56(80)67-46(30-36-17-11-10-12-18-36)57(81)71-58(82)48(32-50(73)74)70-59(83)87-60(3,4)5/h6,8,10-14,17-20,22,24-27,34,39,42,44-49,63-64,72H,1,7,9,15-16,21,23,28-33,35,61-62H2,2-5H3,(H,65,76)(H,66,79)(H,67,80)(H,68,77)(H,69,78)(H,70,83)(H,73,74)(H,71,81,82)(H,84,85,86)/b19-8+/t39-,42-,44+,45-,46-,47-,48+,49-/m0/s1

SMILES Code

CCCC[C@H](NC([C@@H](NC([C@H](NC[C@@H](NC([C@@H](N)Cc1ccc(O)cc1)=O)/C=C/C=C)CCCCN)=O)Cc2c3ccccc3[nH]c2)=O)C(N[C@H](C(N[C@H](C(NC([C@H](NC(OC(C)(C)C)=O)CC(O)=O)=O)=O)Cc4ccccc4)=O)CC(OS(=O)(O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,260.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Derrien M, McCort-Tranchepain I, Ducos B, Roques BP, Durieux C. Heterogeneity of CCK-B receptors involved in animal models of anxiety. Pharmacol Biochem Behav. 1994 Sep;49(1):133-41. PubMed PMID: 7816864. 2: Léna I, Simon H, Roques BP, Daugé V. Opposing effects of two CCK(B) agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat. Neuropharmacology. 1999 Apr;38(4):543-53. PubMed PMID: 10221758. 3: Léna I, Roques BP, Durieux C. Dual modulation of dopamine release from anterior nucleus accumbens through cholecystokinin-B receptor subsites. J Neurochem. 1997 Jan;68(1):162-8. PubMed PMID: 8978722. 4: Heidbreder C, Roques BP, De Witte P. Similar potencies of CCK-8 and its analogue BOC(Nle28;Nle31)CCK27-33 on the self-stimulation behaviour both are antagonized by a newly synthesized cyclic CCK analogue. Neuropeptides. 1989 Feb-Mar;13(2):89-94. PubMed PMID: 2739884. 5: Derrien M, Durieux C, Roques BP. Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole. Br J Pharmacol. 1994 Mar;111(3):956-60. PubMed PMID: 8019773; PubMed Central PMCID: PMC1910081. 6: Léna I, Dh tel H, Garbay C, Daugé V. Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens. Psychopharmacology (Berl). 2001 Jan 1;153(2):170-9. PubMed PMID: 11205416. 7: Durieux C, Derrien M, Maldonado R, Valverde O, Blommaert A, Fournié-Zaluski MC, Roques BP. CCK-B antagonists exhibit antidepressant-like effects and potentiate endogenous enkephalin analgesia. Correlation with in vivo binding affinities and brain penetration. Ann N Y Acad Sci. 1994 Mar 23;713:355-7. PubMed PMID: 8185186. 8: Ladurelle N, Sebret A, Garbay C, Roques BP, Daugé V. Opposite effects of CCK(B) agonists in grooming behaviour in rats: further evidence for two CCK(B) subsites. Br J Pharmacol. 1998 Jul;124(6):1091-8. PubMed PMID: 9720778; PubMed Central PMCID: PMC1565489.