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MedKoo Cat#: 414782 | Name: Parecoxib Free Base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Parecoxib Free Base, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved through much of Europe for short term perioperative pain control. It was patented in 1996 and approved for medical use in 2002.

Chemical Structure

Parecoxib Free Base
Parecoxib Free Base
CAS#198470-84-7 (free base)

Theoretical Analysis

MedKoo Cat#: 414782

Name: Parecoxib Free Base

CAS#: 198470-84-7 (free base)

Chemical Formula: C19H18N2O4S

Exact Mass: 370.0987

Molecular Weight: 370.42

Elemental Analysis: C, 61.61; H, 4.90; N, 7.56; O, 17.28; S, 8.65

Price and Availability

Size Price Availability Quantity
25mg USD 600.00 2 Weeks
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Related CAS #
198470-84-7 (free base); 198470-85-8 (sodium)
Synonym
Parecoxib Free Base; SC69124; SC-69124; SC 69124
IUPAC/Chemical Name
Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-
InChi Key
TZRHLKRLEZJVIJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)
SMILES Code
CCC(NS(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hsieh CY, Sun CH, Lin CC, Chou YF. Comparative Analysis of Ketorolac and Parecoxib for Postoperative Pain Management in Uvulopalatopharyngoplasty. J Clin Med. 2024 Jul 28;13(15):4422. doi: 10.3390/jcm13154422. PMID: 39124688; PMCID: PMC11312481. 2: Biase TMMA, Rocha JGM, Silva MT, Ribeiro-Vaz I, Galvão TF. Renal effects of selective cyclooxygenase-2 inhibitor anti-inflammatory drugs: A systematic review and meta-analysis. Explor Res Clin Soc Pharm. 2024 Jul 8;15:100475. doi: 10.1016/j.rcsop.2024.100475. PMID: 39114538; PMCID: PMC11304066. 3: Chang WL, Peng JY, Hong CL, Li PC, Lu FJ, Chen CH. Parecoxib and 5-Fluorouracil Synergistically Inhibit EMT and Subsequent Metastasis in Colorectal Cancer by Targeting PI3K/Akt/NF-κB Signaling. Biomedicines. 2024 Jul 9;12(7):1526. doi: 10.3390/biomedicines12071526. PMID: 39062099; PMCID: PMC11274433. 4: Tian L, Huang Y, Liu Y, Liu J, Liu Y. Parecoxib inhibits tumorigenesis and angiogenesis in hepatocellular carcinoma through ERK-VEGF/MMPs signaling pathway. IUBMB Life. 2024 Jun 14. doi: 10.1002/iub.2861. Epub ahead of print. PMID: 38873890. 5: Cao L, Zhang L, Chen B, Yan L, Shi X, Tian L. Application of multimodal standardized analgesia under the concept of enhanced recovery after surgery in laparoscopic radical colorectal cancer surgery. Front Oncol. 2024 May 21;14:1381809. doi: 10.3389/fonc.2024.1381809. PMID: 38835370; PMCID: PMC11148287. 6: Hallengren S, Schening A, Lindström AC, Radros J, Eriksson J, Blomqvist E, Knutas R, Fällman N, Aly M, Gupta A. Postoperative pain, recovery and discharge after robot-assisted laparoscopic prostatectomy: A multicentre, single blinded, randomised controlled trial. Acta Anaesthesiol Scand. 2024 Sep;68(8):1006-1015. doi: 10.1111/aas.14465. Epub 2024 Jun 3. PMID: 38828497. 7: Zhang X, Zhang C, Zheng X, Xu A, Chen P. The Laparoscopic Right-lower Quadrant Approach for the Treatment of Right-sided Colon Cancer Offers Advantages Such as Shorter Surgical Time and Less Blood Loss. Altern Ther Health Med. 2024 May 17:AT10266. Epub ahead of print. PMID: 38758145. 8: Li CW, Liaw WJ, Wang YH, Lin HY. Analgesic Effectiveness of Dinalbuphine Sebacate in Video-Assisted Thoracoscopic Wedge Resection and Its Effect on Reducing Postoperative Pulmonary Complications: A Retrospective Cohort Study. Asian J Anesthesiol. 2023 Dec 1;61(4):183-193. doi: 10.6859/aja.202312_61(4).0005. Epub 2023 Dec 1. PMID: 38695069. 9: Sarridou D, Gkiouliava A, Argiriadou H, Varrassi G, Chalmouki G, Vadalouca A, Moka E. The Efficacy of the Combination of Continuous Femoral Nerve Block and Intravenous Parecoxib on Rehabilitation in Patients Undergoing Total Knee Arthroplasty: A Double-Blind, Randomized Clinical Trial. Cureus. 2024 Mar 18;16(3):e56420. doi: 10.7759/cureus.56420. PMID: 38638774; PMCID: PMC11024488. 10: Li J, Chen H, Zuo J, Zhang X. Effect of fascia iliaca compartment block combined with ropivacaine on post-operative outcomes in elderly patients undergoing hip fracture repair. Pak J Med Sci. 2024 Mar-Apr;40(4):757-762. doi: 10.12669/pjms.40.4.8283. PMID: 38544994; PMCID: PMC10963986. 11: Iamthanaporn K, Rojjanasirisawat N, Yuenyongviwat V. Letter re: Reply: Letter to editor: Superior analgesic efficacy of preemptive low-dose ketorolac compared with parecoxib after total knee arthroplasty: A retrospective propensity score matching study. J Orthop Surg (Hong Kong). 2024 Jan- Apr;32(1):10225536241241897. doi: 10.1177/10225536241241897. PMID: 38533837. 12: Tian Z, Wei Z, Wang J, Meng C. Letter re: Letter to the editor: Superior analgesic efficacy of preemptive low-dose ketorolac compared with parecoxib after total knee arthroplasty: A retrospective propensity score matching study. J Orthop Surg (Hong Kong). 2024 Jan-Apr;32(1):10225536241241893. doi: 10.1177/10225536241241893. PMID: 38529811. 13: Vaja R, Lopes-Pires M, Shala F, Cypaite N, Vinokurova M, Ferreira P, Mitchell JA, Kirkby NS. L-arginine supplementation protects against thrombosis and renal dysfunction in mice treated with the cyclooxygenase-2 inhibitor parecoxib. J Thromb Haemost. 2024 Jun;22(6):1798-1801. doi: 10.1016/j.jtha.2024.03.006. Epub 2024 Mar 20. PMID: 38518895. 14: Wu R, Liu R, Zhang Y, Li X. [Parecoxib sodium down-regulates CXCL8-CXCR1/2 to improve inflammatory microenvironment and promote patient recovery following laparoscopic radical resection of rectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Feb 20;44(2):363-369. Chinese. doi: 10.12122/j.issn.1673-4254.2024.02.19. PMID: 38501422; PMCID: PMC10954531. 15: Grella R, Lanzano G, Faenza M, Ferraro G, Pieretti G. Parecoxib decreases cellular growth and Bcl-2 protein levels in primary cultures of keloid fibroblasts. Int Wound J. 2024 Mar;21(3):e13946. doi: 10.1111/iwj.13946. PMID: 38477426; PMCID: PMC10935549. 16: Huang YY, Ng YT, Chiu CH, Chuang CA, Sheu H, Yang CP, Tang HC. Addition of Preoperative Ultrasound-Guided Suprascapular Nerve Block and Axillary Nerve Block to Parecoxib Is More Effective in Early Postoperative Pain Control After Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Study. Arthroscopy. 2024 Mar 4:S0749-8063(24)00166-X. doi: 10.1016/j.arthro.2024.02.031. Epub ahead of print. PMID: 38447626. 17: Zhao A, Guo D, Zhu M, Gao A, Li P, Fu A. Incidence, characteristics, and risk factors of drug-associated muscle adverse reaction: a retrospective real- world study of inpatients. Eur J Clin Pharmacol. 2024 Jun;80(6):911-918. doi: 10.1007/s00228-024-03662-0. Epub 2024 Mar 5. PMID: 38441574. 18: Huang D, Zhang Z, Jian J, Jiang X, Gao J, Yang M, Ding X. Parecoxib sodium attenuates acute lung injury following burns by regulating M1/M2 macrophage polarization through the TLR4/NF-κB pathway. Eur J Pharmacol. 2024 Apr 5;968:176407. doi: 10.1016/j.ejphar.2024.176407. Epub 2024 Feb 15. PMID: 38365106. 19: Cheng CC, Yeh HC, Su PW, Ho CL, Chang SC. Risk factors of chronic kidney disease in cisplatin-based hyperthermia intraperitoneal chemotherapy. Int J Hyperthermia. 2024;41(1):2304250. doi: 10.1080/02656736.2024.2304250. Epub 2024 Feb 11. PMID: 38342495. 20: Hu CY, Wang JH, Chen TY, Wang PK. Associations of parecoxib and other variables with recovery and safety outcomes in total knee arthroplasty: insights from a retrospective cohort study. Front Surg. 2024 Jan 4;10:1308221. doi: 10.3389/fsurg.2023.1308221. PMID: 38239668; PMCID: PMC10794493.