BBDDL2059 is a highly potent and selective covalent inhibitor. BBDDL2059 inhibits EZH2 enzymatic activity at sub-nanomolar concentrations and achieves low nanomolar potencies in cell growth inhibition. BBDDL2059 is noncompetitive with the cofactor SAM, providing the basis for its superior activity over noncovalent and positive controls by reducing competition with cofactor SAM and offering a preliminary proof for its covalent inhibition nature
MedKoo Cat#: 123649
Name: BBDDL2059
CAS#: N/A
Chemical Formula: C27H36N4O4S
Exact Mass: 512.2500
Molecular Weight: 512.67
Elemental Analysis: C, 63.26; H, 7.08; N, 10.93; O, 12.48; S, 6.25
The following data is based on the product molecular weight 512.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
