Synonym
Vanoxonin; Antibiotic MG 245CF2A; Antibiotic MG-245CF2A; Antibiotic MG245CF2A; MG-245-CF2-A;
IUPAC/Chemical Name
(S)-2-((2S,3R)-2-(2,3-dihydroxybenzamido)-3-hydroxybutanamido)-5-(N-hydroxyacetamido)pentanoic acid
InChi Key
KCWDMHXDGAWLOA-LQJRIPTKSA-N
InChi Code
InChI=1S/C18H25N3O9/c1-9(22)14(20-16(26)11-5-3-7-13(24)15(11)25)17(27)19-12(18(28)29)6-4-8-21(30)10(2)23/h3,5,7,9,12,14,22,24-25,30H,4,6,8H2,1-2H3,(H,19,27)(H,20,26)(H,28,29)/t9-,12+,14+/m1/s1
SMILES Code
O=C(O)[C@H](CCCN(C(C)=O)O)NC([C@H]([C@H](O)C)NC(C1=CC=CC(O)=C1O)=O)=O
Purity
>80% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
427.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kanai F, Isshiki K, Umezawa Y, Morishima H, Naganawa H, Takita T, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate synthetase. II. Structure determination and total synthesis. J Antibiot (Tokyo). 1985 Jan;38(1):31-8. PubMed PMID: 3972726.
2: Kanai F, Sawa T, Hamada M, Naganawa H, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate synthetase. J Antibiot (Tokyo). 1983 Jun;36(6):656-60. PubMed PMID: 6874588.
3: Kanai F, Kaneko T, Morishima H, Isshiki K, Takita T, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex. J Antibiot (Tokyo). 1985 Jan;38(1):39-50. PubMed PMID: 3972727.
