Synonym
L 654284; L-654284; L654284; L-654,284; L 654,284; L654,284; Hbfqmh;
IUPAC/Chemical Name
2-hydroxy-N-methyl-N-(2,3,4,5,6,7,12,13-octahydrofuro[2,3-d]pyrido[1,2-b]isoquinolin-2-yl)ethane-1-sulfonamide
InChi Key
RYAGNCTZBHVAFQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H26N2O4S/c1-19(25(22,23)11-10-21)16-12-18-8-4-2-6-14(18)13-20-9-5-3-7-15(20)17(18)24-16/h5,9,13,16,21H,2-4,6-8,10-12H2,1H3
SMILES Code
OCCS(=O)(N(C(O1)CC23C1=C4CCC=CN4C=C2CCCC3)C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
366.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Randall WC, Huff JR, Vacca JP, Guare JP, Chen R, Rosegay A, Baldwin JJ. [3H]L-654,284 as a probe of the central alpha 2 adrenoceptor. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):47-52. PubMed PMID: 2907099.
2: Pettibone DJ, Clineschmidt BV, Lotti VJ, Martin GE, Huff JR, Randall WC, Vacca J, Baldwin JJ. L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):110-6. PubMed PMID: 2875395.
3: Huff JR, Anderson PS, Baldwin JJ, Clineschmidt BV, Guare JP, Lotti VJ, Pettibone DJ, Randall WC, Vacca JP. N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist. J Med Chem. 1985 Dec;28(12):1756-9. PubMed PMID: 2999400.
