MedKoo Cat#: 563410 | Name: U-99194 maleate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

U-99194 maleate is a selective dopamine D3 receptor antagonist that modulates dopaminergic signaling in the brain. Its mechanism of action involves blocking D3 receptor activity, which is implicated in reward, motivation, and neuropsychiatric disorders. Due to its effects on dopamine pathways, U-99194 has been investigated for potential applications in treating addiction, depression, and schizophrenia.

Chemical Structure

U-99194 maleate
U-99194 maleate
CAS#234757-41-6 (maleate)

Theoretical Analysis

MedKoo Cat#: 563410

Name: U-99194 maleate

CAS#: 234757-41-6 (maleate)

Chemical Formula: C21H31NO6

Exact Mass: 0.0000

Molecular Weight: 393.48

Elemental Analysis: C, 64.10; H, 7.94; N, 3.56; O, 24.40

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,350.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
82668-33-5 (free base) 234757-41-6 (maleate)
Synonym
U-99194 maleate; U 99194 maleate; U99194 maleate; U-99194A; U 99194A; U99194A; U 99194 A; U-99194-A;
IUPAC/Chemical Name
5,6-Dimethoxy-2-(di-n-propylamino)indan maleate salt
InChi Key
FSIQDESGRQTFNN-BTJKTKAUSA-N
InChi Code
InChI=1S/C17H27NO2.C4H4O4/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;5-3(6)1-2-4(7)8/h11-12,15H,5-10H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
CCCN(C1CC2=C(C=C(OC)C(OC)=C2)C1)CCC.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 393.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kato M, Kunisawa N, Shimizu S, Iha HA, Ohno Y. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. doi: 10.3389/fphar.2022.938175. PMID: 35784764; PMCID: PMC9243423. 2: Newton CL, Wood MD, Strange PG. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. PLoS One. 2016 Jul 5;11(7):e0158808. doi: 10.1371/journal.pone.0158808. PMID: 27379794; PMCID: PMC4933336. 3: Eguibar JR, Cortés Mdel C, Lara-Lozano M. Presynaptic dopaminergic agonists increased gripping-generated immobility episodes in the myelin-mutant taiep rat. Neurosci Lett. 2010 Oct 15;483(3):189-92. doi: 10.1016/j.neulet.2010.07.086. Epub 2010 Aug 6. PMID: 20692320. 4: Sander SE, Raymond R, Nobrega JN, Richter A. Autoradiographic and pharmacological studies on the role of dopamine D3 receptors in genetically dystonic (dt(sz)) hamsters. Pharmacol Biochem Behav. 2010 Aug;96(2):136-40. doi: 10.1016/j.pbb.2010.04.021. Epub 2010 May 6. PMID: 20451545. 5: Iasevoli F, Tomasetti C, Ambesi-Impiombato A, Muscettola G, de Bartolomeis A. Dopamine receptor subtypes contribution to Homer1a induction: insights into antipsychotic molecular action. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):813-21. doi: 10.1016/j.pnpbp.2009.02.009. Epub 2009 Feb 23. PMID: 19243698. 6: Casarrubea M, Sorbera F, Crescimanno G. Effects of 7-OH-DPAT and U 99194 on the behavioral response to hot plate test, in rats. Physiol Behav. 2006 Nov 30;89(4):552-62. doi: 10.1016/j.physbeh.2006.07.014. Epub 2006 Aug 17. PMID: 16919688. 7: Bastianetto S, Danik M, Mennicken F, Williams S, Quirion R. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci. 2006 Mar 30;7:28. doi: 10.1186/1471-2202-7-28. PMID: 16573831; PMCID: PMC1448194. 8: Hammad H, Wagner JJ. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316(1):113-20. doi: 10.1124/jpet.105.091579. Epub 2005 Sep 14. PMID: 16162819. 9: Hale MW, Crowe SF. The effects of selective dopamine agonists on a passive avoidance learning task in the day-old chick. Behav Pharmacol. 2002 Jul;13(4):295-301. doi: 10.1097/00008877-200207000-00006. PMID: 12218510. 10: Zou L, Jankovic J, Rowe DB, Xie W, Appel SH, Le W. Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity. Life Sci. 1999;64(15):1275-85. doi: 10.1016/s0024-3205(99)00062-4. PMID: 10227583. 11: Audinot V, Newman-Tancredi A, Gobert A, Rivet JM, Brocco M, Lejeune F, Gluck L, Desposte I, Bervoets K, Dekeyne A, Millan MJ. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97. PMID: 9765337.