HP 228 | CAS#109022-88-0 | nitric oxide synthase inhibitor

MedKoo Cat#: 597675 | Name: HP 228

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HP 228 is a heptapeptide. HP 228 inhibits the induction of nitric oxide synthase.

Chemical Structure

HP 228

CAS#109022-88-0

Theoretical Analysis

MedKoo Cat#: 597675

Name: HP 228

CAS#: 109022-88-0

Chemical Formula: C45H63N15O8

Exact Mass: 941.4984

Molecular Weight: 942.09

Elemental Analysis: C, 57.37; H, 6.74; N, 22.30; O, 13.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HP 228; HP-228; HP228; Ac-Nle-gln-his-D-phe-arg-D-trp-gly-NH2;

IUPAC/Chemical Name

(S)-N1-((5S,8S,11S,14S)-5-((1H-indol-3-yl)methyl)-1-amino-11-benzyl-8-(3-guanidinopropyl)-15-(1H-imidazol-4-yl)-1,4,7,10,13-pentaoxo-3,6,9,12-tetraazapentadecan-14-yl)-2-((S)-2-aminohexanamido)pentanediamide

InChi Key

OLHUSXUJHZVGLZ-VCAFKBFISA-N

InChi Code

InChI=1S/C45H63N15O8/c1-2-3-13-30(46)39(63)56-33(16-17-37(47)61)42(66)60-36(21-28-23-51-25-55-28)44(68)58-34(19-26-10-5-4-6-11-26)43(67)57-32(15-9-18-52-45(49)50)41(65)59-35(40(64)54-24-38(48)62)20-27-22-53-31-14-8-7-12-29(27)31/h4-8,10-12,14,22-23,25,30,32-36,53H,2-3,9,13,15-21,24,46H2,1H3,(H2,47,61)(H2,48,62)(H,51,55)(H,54,64)(H,56,63)(H,57,67)(H,58,68)(H,59,65)(H,60,66)(H4,49,50,52)/t30-,32-,33-,34-,35-,36-/m0/s1

SMILES Code

O=C(N)CNC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCNC(N)=N)NC([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CNC=N4)NC([C@H](CCC(N)=O)NC([C@H](CCCC)N)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 942.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Weinger MB, Chaplan SR, Girten BE, Powell FL. The respiratory effects of the cytokine regulating agent HP 228 alone and in combination with morphine in human volunteers. Pharmacol Biochem Behav. 1998 Mar;59(3):759-66. PubMed PMID: 9512083. 2: Abou-Mohamed G, Papapetropoulos A, Ulrich D, Catravas JD, Tuttle RR, Caldwell RW. HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro. J Pharmacol Exp Ther. 1995 Nov;275(2):584-91. PubMed PMID: 7473142. 3: Schiöth HB, Muceniece R, Wikberg JE. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides. 1997 Dec;31(6):565-71. PubMed PMID: 9574823. 4: Girten B, McPherson S, Lee M, Grethe N, McDowell R, McPherson L, Tuttle RR. Effectiveness of a cytokine restraining agent (CRA (TM)) in attenuating disuse deconditioning induced by hindlimb unloading in rats. J Gravit Physiol. 1995;2(1):P121-2. PubMed PMID: 11538892. 5: Getting SJ, Di Filippo C, D'Amico M, Perretti M. The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. Eur J Pharmacol. 2006 Feb 17;532(1-2):138-44. Epub 2006 Jan 25. PubMed PMID: 16442098. 6: Nordheim U, Nicholson JR, Dokladny K, Dunant P, Hofbauer KG. Cardiovascular responses to melanocortin 4-receptor stimulation in conscious unrestrained normotensive rats. Peptides. 2006 Feb;27(2):438-43. Epub 2005 Nov 7. PubMed PMID: 16274849. 7: Calcutt NA, Dines KC, Ceseña RM. Effects of the peptide HP228 on nerve disorders in diabetic rats. Metabolism. 1998 Jun;47(6):650-6. PubMed PMID: 9627361.