OP-1250 is a potent orally available complete antagonist of estrogen receptor-mediated signaling that shrinks wild type and mutant breast tumors. OP-1250 shows good oral bioavailability and favorable pharmacokinetics, a combination that may particularly benefit ER+ resistant tumors in which the receptor acquires activating mutations that confer estrogen-independent agonist activity.
MedKoo Cat#: 124045
Name: OP-1250
CAS#: N/A
Chemical Formula: C28H34F3N3O
Exact Mass: 485.2700
Molecular Weight: 485.60
Elemental Analysis: C, 69.26; H, 7.06; F, 11.74; N, 8.65; O, 3.29
The following data is based on the product molecular weight 485.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
