Nardosinone | CAS# 23720-80-1 | Biochemical

MedKoo Cat#: 577972 | Name: Nardosinone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nardosinone is a biochemical with anti-inflammatory and anti-hypertrophic properties. This product has been shown to enhance nerve growth factor activity and promote proliferation and differentiation of neural stem cells.

Chemical Structure

Nardosinone

CAS#23720-80-1

Theoretical Analysis

MedKoo Cat#: 577972

Name: Nardosinone

CAS#: 23720-80-1

Chemical Formula: C15H22O3

Exact Mass: 250.1569

Molecular Weight: 250.34

Elemental Analysis: C, 71.97; H, 8.86; O, 19.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Nardosinone

IUPAC/Chemical Name

(3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one

InChi Key

KXGHHSIMRWPVQM-JWFUOXDNSA-N

InChi Code

InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1

SMILES Code

C[C@@H]1CCC=C2C(=O)C[C@H]3OOC(C)(C)[C@H]3[C@@]12C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 250.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Wen J, Liu L, Li J, He Y. A review of nardosinone for pharmacological activities. Eur J Pharmacol. 2021 Oct 5;908:174343. doi: 10.1016/j.ejphar.2021.174343. Epub 2021 Jul 12. PMID: 34265296. 2. Bian LH, Yao ZW, Zhao CB, Li QY, Shi JL, Guo JY. Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor. Evid Based Complement Alternat Med. 2021 Aug 13;2021:6686965. doi: 10.1155/2021/6686965. PMID: 34426745; PMCID: PMC8380167. 3. Niu C, Xiao F, Yuan K, Hu X, Lin W, Ma R, Zhang X, Huang Z. Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption. Front Pharmacol. 2017 Sep 12;8:626. doi: 10.3389/fphar.2017.00626. PMID: 28955231; PMCID: PMC5601052. 4. Du M, Huang K, Gao L, Yang L, Wang WS, Wang B, Huang K, Huang D. Nardosinone protects H9c2 cardiac cells from angiotensin II-induced hypertrophy. J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):822-826. doi: 10.1007/s11596-013-1205-9. Epub 2013 Dec 13. PMID: 24337842.