Synonym
MF 13; MF-13; MF13; MF13 Cpd; MF13-Cpd; MF13Cpd; Pro-3-bca-phe-nva ethyl ester;
IUPAC/Chemical Name
(S)-2-((S)-3-(3-(bis(2-chloroethyl)amino)phenyl)-2-((S)-pyrrolidine-2-carboxamido)propanamido)pentanoic acid
InChi Key
CVOHDTBZTILHDL-UFYCRDLUSA-N
InChi Code
InChI=1S/C23H34Cl2N4O4/c1-2-5-19(23(32)33)27-22(31)20(28-21(30)18-8-4-11-26-18)15-16-6-3-7-17(14-16)29(12-9-24)13-10-25/h3,6-7,14,18-20,26H,2,4-5,8-13,15H2,1H3,(H,27,31)(H,28,30)(H,32,33)/t18-,19-,20-/m0/s1
SMILES Code
CCC[C@@H](C(O)=O)NC([C@H](CC1=CC=CC(N(CCCl)CCCl)=C1)NC([C@H]2NCCC2)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
501.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Roboz J, Jiang J, Holland JF, Bekesi JG. Selective tumor apoptosis by MF13, L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester, a new sarcolysin containing tripeptide. Cancer Res. 1997 Nov 1;57(21):4795-802. PubMed PMID: 9354441.
2: Jiang JD, Zhang H, Li JN, Roboz J, Qiao WB, Holland JF, Bekesi G. High anticancer efficacy of L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride (MF13) in vivo. Anticancer Res. 2001 May-Jun;21(3B):1681-9. PubMed PMID: 11497247.
3: Hu QY, Li JN, Song DQ, Wang YL, Bekesi G, Weisz I, Jiang JD. Inhibition of human hepatocellular carcinoma by L-proline-m-bis (2-chloroethyl) amino-L-phenylalanyl-L-norvaline ethyl ester hydrochloride (MF13) in vitro and in vivo. Int J Oncol. 2004 Nov;25(5):1289-96. PubMed PMID: 15492817.
