MedKoo Cat#: 130353 | Name: Biotin-Thalidomide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Biotin-Thalidomide is a cereblon affinity probe for use in the development of PROTACs and studying protein degradation. Furthermore, Biotin-Thalidomide also plays a key role in research on cereblon and applications of cereblon with relation to protein degraders.

Chemical Structure

Biotin-Thalidomide
Biotin-Thalidomide
CAS# 2230857-87-9

Theoretical Analysis

MedKoo Cat#: 130353

Name: Biotin-Thalidomide

CAS#: 2230857-87-9

Chemical Formula: C44H64N8O13S

Exact Mass: 944.4314

Molecular Weight: 945.10

Elemental Analysis: C, 55.92; H, 6.83; N, 11.86; O, 22.01; S, 3.39

Price and Availability

Size Price Availability Quantity
1mg USD 650.00 2 Weeks
5mg USD 1,250.00 2 Weeks
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Related CAS #
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Synonym
Biotin-Thalidomide; Biotin-conjugated thalidomide; bio-Thal
IUPAC/Chemical Name
N1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide
InChi Key
UCTZYEDSVDZJQR-NTZPKYJMSA-N
InChi Code
InChI=1S/C44H64N8O13S/c53-34(12-2-1-11-33-40-30(28-66-33)49-44(61)51-40)46-19-7-21-62-23-25-64-26-24-63-22-8-20-47-36(55)14-6-13-35(54)45-17-3-4-18-48-38(57)27-65-32-10-5-9-29-39(32)43(60)52(42(29)59)31-15-16-37(56)50-41(31)58/h5,9-10,30-31,33,40H,1-4,6-8,11-28H2,(H,45,54)(H,46,53)(H,47,55)(H,48,57)(H2,49,51,61)(H,50,56,58)/t30-,31?,33-,40-/m0/s1
SMILES Code
O=C(N1)C(N(C(C2=C3C=CC=C2OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@@]5([H])NC(N[C@]5(CS4)[H])=O)=O)=O)=O)=O)=O)C3=O)CCC1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 945.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441. doi: 10.1038/s41589-018-0021-8. Epub 2018 Mar 26. PMID: 29581585; PMCID: PMC6295913.