MedKoo Cat#: 558367 | Name: ProINDY
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ProINDY, also known as TG007, is a potent ATP-competitive Dyrk1A inhibitor.

Chemical Structure

ProINDY
ProINDY
CAS#719277-30-2

Theoretical Analysis

MedKoo Cat#: 558367

Name: ProINDY

CAS#: 719277-30-2

Chemical Formula: C14H15NO3S

Exact Mass: 277.0800

Molecular Weight: 277.34

Elemental Analysis: C, 60.63; H, 5.45; N, 5.05; O, 17.31; S, 11.56

Price and Availability

Size Price Availability Quantity
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,450.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Related CAS #
No Data
Synonym
TG007; TG-007; TG 007; ProINDY;
IUPAC/Chemical Name
[(2Z)-3-ethyl-2-(2-oxopropylidene)-1,3-benzothiazol-5-yl] acetate
InChi Key
RLEOCVDWLAYGRX-AUWJEWJLSA-N
InChi Code
InChI=1S/C14H15NO3S/c1-4-15-12-8-11(18-10(3)17)5-6-13(12)19-14(15)7-9(2)16/h5-8H,4H2,1-3H3/b14-7-
SMILES Code
CC(OC1=CC=C(S/C(N2CC)=C\C(C)=O)C2=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tucker Edmister S, Ibrahim R, Kakodkar R, Kreiling JA, Creton R. A zebrafish model for calcineurin-dependent brain function. Behav Brain Res. 2022 Jan 7;416:113544. doi: 10.1016/j.bbr.2021.113544. Epub 2021 Aug 20. PMID: 34425181; PMCID: PMC8903086. 2: Tucker Edmister S, Creton R. Modulation of calcineurin signaling during development. Dev Neurobiol. 2022 Sep;82(6):505-516. doi: 10.1002/dneu.22895. Epub 2022 Jul 10. PMID: 35785416; PMCID: PMC9922048. 3: Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010 Oct 5;1:86. doi: 10.1038/ncomms1090. PMID: 20981014. 4: Kim H, Lee KS, Kim AK, Choi M, Choi K, Kang M, Chi SW, Lee MS, Lee JS, Lee SY, Song WJ, Yu K, Cho S. A chemical with proven clinical safety rescues Down- syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech. 2016 Aug 1;9(8):839-48. doi: 10.1242/dmm.025668. Epub 2016 Jul 7. PMID: 27483355; PMCID: PMC5007978.