VER-155008 | CAS#1134156-31-2 | HSP70 inhibitor

MedKoo Cat#: 563200 | Name: VER-155008

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VER-155008 is an inhibitor of HSP70. It acts by inhibiting reactivation of firefly luciferase.

Chemical Structure

VER-155008

CAS#1134156-31-2

Theoretical Analysis

MedKoo Cat#: 563200

Name: VER-155008

CAS#: 1134156-31-2

Chemical Formula: C25H23Cl2N7O4

Exact Mass: 555.1189

Molecular Weight: 556.40

Elemental Analysis: C, 53.97; H, 4.17; Cl, 12.74; N, 17.62; O, 11.50

Price and Availability

Size	Price	Availability
10mg	USD 320.00
25mg	USD 640.00	2 Weeks
50mg	USD 1,100.00	2 Weeks

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Related CAS #

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Synonym

VER-155008; VER 155008; VER155008;

IUPAC/Chemical Name

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

InChi Key

ZXGGCBQORXDVTE-UMCMBGNQSA-N

InChi Code

InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

SMILES Code

O[C@@H]([C@H]([C@H](N1C(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C(N=CN=C31)N)O4)O)[C@H]4COCC5=CC=C(C#N)C=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 556.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xu SM, Liu XZ, Wang L, Huang WH, Hu YT, Chen SB, Huang ZS, Huang SL. Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 14;1871(3):167630. doi: 10.1016/j.bbadis.2024.167630. Epub ahead of print. PMID: 39675530. 2: Xiao Z, Wang Y, Chen Y, Jin L, Shi Y, Liu C, Fu C, Cao Y. Exosomes derived from TREM-2 knocked-out macrophages alleviated renal fibrosis via HSPa1b/AKT pathway. Am J Physiol Renal Physiol. 2024 Dec 10. Epub ahead of print. PMID: 39657110. 3: Alhasan B, Gladova YA, Sverchinsky DV, Aksenov ND, Margulis BA, Guzhova IV. Hsp70 Negatively Regulates Autophagy via Governing AMPK Activation, and Dual Hsp70-Autophagy Inhibition Induces Synergetic Cell Death in NSCLC Cells. Int J Mol Sci. 2024 Aug 22;25(16):9090. doi: 10.3390/ijms25169090. PMID: 39201776; PMCID: PMC11354248. 4: Wang Q, Wei J, He J, Ming S, Li X, Huang X, Hong Z, Wu Y. HSP70 contributes to pathogenesis of fulminant hepatitis induced by coronavirus. Int Immunopharmacol. 2024 Nov 15;141:112963. doi: 10.1016/j.intimp.2024.112963. Epub 2024 Aug 18. PMID: 39159560. 5: Zhu J, Li B, Fang W, Zhou X, Li D, Jin J, Li W, Su Y, Yuan R, Ye JM, Wu R. Oral matrine alleviates CCl4-induced liver fibrosis via preserved HSP72 from modulated gut microbiota. Biomed Pharmacother. 2024 Sep;178:117262. doi: 10.1016/j.biopha.2024.117262. Epub 2024 Aug 6. PMID: 39111080. 6: Wu E, Wu C, Jia K, Zhou S, Sun L. HSPA8 inhibitors augment cancer chemotherapeutic effectiveness via potentiating necroptosis. Mol Biol Cell. 2024 Aug 1;35(8):ar108. doi: 10.1091/mbc.E24-04-0194. Epub 2024 Jul 3. PMID: 38959101; PMCID: PMC11321035. 7: Yu SH, Yoon I, Kim YJ. Ex vivo photothermal treatment-induced immunogenic cell death for anticancer vaccine development. Int Immunopharmacol. 2024 Jan 25;127:111450. doi: 10.1016/j.intimp.2023.111450. Epub 2023 Dec 28. PMID: 38157695. 8: Liu Y, Han T, Wu J, Zhou J, Guo J, Miao R, Xu Z, Xing Y, Bai Y, Hu D. SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion. J Transl Med. 2023 Dec 12;21(1):909. doi: 10.1186/s12967-023-04616-3. PMID: 38087364; PMCID: PMC10717042. 9: Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. HSP70 inhibitor amplifies the bFGF‑induced release of IL‑6 in osteoblasts. Mol Med Rep. 2023 Dec;28(6):230. doi: 10.3892/mmr.2023.13117. Epub 2023 Oct 27. PMID: 37888538. 10: Zhang T, Yan W, Liu C, Duan W, Duan Y, Li Y, Yu Q, Sun Y, Tian J, Zhou J, Xia Z, Wang G, Xu S. Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish. Ecotoxicol Environ Saf. 2023 Sep 15;263:115241. doi: 10.1016/j.ecoenv.2023.115241. Epub 2023 Jul 11. PMID: 37441943. 11: Braune-Yan M, Jia J, Wahba M, Schmid J, Papatheodorou P, Barth H, Ernst K. Domperidone Protects Cells from Intoxication with Clostridioides difficile Toxins by Inhibiting Hsp70-Assisted Membrane Translocation. Toxins (Basel). 2023 Jun 7;15(6):384. doi: 10.3390/toxins15060384. PMID: 37368685; PMCID: PMC10305128. 12: Hill SE, Beaulieu-Abdelahad D, Lemus A, Webster JM, Ospina SR, Darling AL, Martin MD, Patel S, Bridenstine L, Swonger R, Paul S, Blackburn R, Calcul L, Dickey CA, Leahy JW, Blair LJ. Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation. ACS Chem Biol. 2023 May 19;18(5):1124-1135. doi: 10.1021/acschembio.2c00919. Epub 2023 May 5. PMID: 37144894; PMCID: PMC10443619. 13: Wu H, Liu L, Ma M, Zhang Y. Modulation of blood-brain tumor barrier for delivery of magnetic hyperthermia to brain cancer. J Control Release. 2023 Mar;355:248-258. doi: 10.1016/j.jconrel.2023.01.072. Epub 2023 Feb 8. PMID: 36736432. 14: Kuroyanagi G, Tachi J, Fujita K, Kawabata T, Sakai G, Nakashima D, Kim W, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O, Tokuda H. HSP70 inhibitors upregulate prostaglandin E1-induced synthesis of interleukin-6 in osteoblasts. PLoS One. 2022 Dec 15;17(12):e0279134. doi: 10.1371/journal.pone.0279134. PMID: 36520821; PMCID: PMC9754267. 15: Rössig A, Hill K, Nörenberg W, Weidenbach S, Zierler S, Schaefer M, Gudermann T, Chubanov V. Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7. Cell Calcium. 2022 Sep;106:102640. doi: 10.1016/j.ceca.2022.102640. Epub 2022 Aug 17. PMID: 36030694. 16: Gao S, Chen H, Zhang X, Zhao J, Wang Z. Cellular protein HSC70 promotes fowl adenovirus serotype 4 replication in LMH cells via interacting with viral 100K protein. Poult Sci. 2022 Jul;101(7):101941. doi: 10.1016/j.psj.2022.101941. Epub 2022 May 4. PMID: 35679674; PMCID: PMC9189218. 17: Mattos DR, Weinman MA, Wan X, Goodall CP, Serrill JD, McPhail KL, Milovancev M, Bracha S, Ishmael JE. Canine osteosarcoma cells exhibit basal accumulation of multiple chaperone proteins and are sensitive to small molecule inhibitors of GRP78 and heat shock protein function. Cell Stress Chaperones. 2022 May;27(3):223-239. doi: 10.1007/s12192-022-01263-3. Epub 2022 Mar 4. PMID: 35244890; PMCID: PMC9106791. 18: Lei Z, Xia X, He Q, Luo J, Xiong Y, Wang J, Tang H, Guan T, Tian Y, Xu S, Cui S. HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells. Mol Carcinog. 2021 Dec;60(12):826-839. doi: 10.1002/mc.23346. Epub 2021 Sep 9. PMID: 34499769. 19: Du Y, Chen Z, Yan P, Zhang C, Duan X, Chen X, Liu M, Kang L, Yang X, Fan Y, Zhang J, Wang R. Arginine-Arginine-Leucine Peptide Targeting Heat Shock Protein 70 for Cancer Imaging. Mol Pharm. 2021 Oct 4;18(10):3750-3762. doi: 10.1021/acs.molpharmaceut.1c00273. Epub 2021 Sep 7. PMID: 34491767. 20: Sojka DR, Hasterok S, Vydra N, Toma-Jonik A, Wieczorek A, Gogler-Pigłowska A, Scieglinska D. Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A. Cells. 2021 Jun 7;10(6):1418. doi: 10.3390/cells10061418. PMID: 34200371; PMCID: PMC8229576.