RD-23 is a potent and selective RET PROTAC. RD-23 effectively inhibited the proliferation of BaF3 cells with various RET mutations, showing IC50 values of 2.4 to 6.5 nM. It selectively induced degradation of the RETG810C mutation via the ubiquitin−proteasome system, with a DC50 (concentration causing50% of protein degradation) value of 11.7 nM. Additionally, RD-23exhibited oral bioavailability and superior antitumor effects compared to LOXO-292 in a Ba/F3-KIF5B-RETG810C xenograft mouse model.
MedKoo Cat#: 128332
Name: RD-23
CAS#: N/A
Chemical Formula: C52H56N12O4
Exact Mass: 912.4547
Molecular Weight: 913.10
Elemental Analysis: C, 68.40; H, 6.18; N, 18.41; O, 7.01
The following data is based on the product molecular weight 913.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
