Leucyl-phenylalanine amide | CAS#38678-60-3 | intermediate

MedKoo Cat#: 597481 | Name: Leucyl-phenylalanine amide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucyl-phenylalanine amide is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the major causative agent in Alzheimer disease (AD).

Chemical Structure

Leucyl-phenylalanine amide

CAS#38678-60-3

Theoretical Analysis

MedKoo Cat#: 597481

Name: Leucyl-phenylalanine amide

CAS#: 38678-60-3

Chemical Formula: C15H23N3O2

Exact Mass: 277.1790

Molecular Weight: 277.36

Elemental Analysis: C, 64.96; H, 8.36; N, 15.15; O, 11.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Leucyl-phenylalanine amide; Leu-phe-NH2;

IUPAC/Chemical Name

(S)-2-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-4-methylpentanamide

InChi Key

HVNQCDIUFGAINF-STQMWFEESA-N

InChi Code

InChI=1S/C15H23N3O2/c1-10(2)8-12(16)15(20)18-13(14(17)19)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H2,17,19)(H,18,20)/t12-,13-/m0/s1

SMILES Code

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 277.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Peyton D, Breslow E. Use of perdeuterated peptides in NMR studies of neurophysin-hormone interaction: demonstration of peptide-specific changes in neurophysin resonances. Biochem Biophys Res Commun. 1985 May 16;128(3):1211-8. PubMed PMID: 4004858.