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MedKoo Cat#: 127143 | Name: LH2−051

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LH2−051 is a DAT inhibitor

Chemical Structure

LH2−051
LH2−051
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127143

Name: LH2−051

CAS#: N/A

Chemical Formula: C27H34N2O3

Exact Mass: 434.2569

Molecular Weight: 434.58

Elemental Analysis: C, 74.62; H, 7.89; N, 6.45; O, 11.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
LH2−051; LH2 051; LH2051
IUPAC/Chemical Name
1-(2-(1H-indol-3-yl)ethyl)-6,7-dimethoxy-2-((tetrahydro-2H-pyran-4-yl)methyl)-1,2,3,4-tetrahydroisoquinoline
InChi Key
WBEFXEHFEBYZEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H34N2O3/c1-30-26-15-20-9-12-29(18-19-10-13-32-14-11-19)25(23(20)16-27(26)31-2)8-7-21-17-28-24-6-4-3-5-22(21)24/h3-6,15-17,19,25,28H,7-14,18H2,1-2H3
SMILES Code
COC1=C(C=C(C(CCC2=CNC3=C2C=CC=C3)N(CC4CCOCC4)CC5)C5=C1)OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yin L, Zhou Y, Liu H, Li Y. LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer disease. Autophagy. 2023 Jun;19(6):1863-1864. doi: 10.1080/15548627.2022.2131247. Epub 2022 Oct 10. PMID: 36215390; PMCID: PMC10262797. 2: Yin L, Zhou J, Li T, Wang X, Xue W, Zhang J, Lin L, Wang N, Kang X, Zhou Y, Liu H, Li Y. Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice. Alzheimers Dement. 2023 Apr;19(4):1343-1357. doi: 10.1002/alz.12776. Epub 2022 Sep 21. PMID: 36130073. 3: Zhou J, Wang N, Wang M, Hu Y, Zhang Z, Gu Z, Wang J, Shou H, Cheng X, Liu H, Li Y, Zhou Y. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer's Disease. J Med Chem. 2024 Jun 3. doi: 10.1021/acs.jmedchem.4c00159. Epub ahead of print. PMID: 38830007.