MedKoo Cat#: 575076 | Name: Ceftizoxime alapivoxil hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceftizoxime alapivoxil hydrochloride is a broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin, binding to and inactivating penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.

Chemical Structure

Ceftizoxime alapivoxil hydrochloride
CAS#135767-36-1

Theoretical Analysis

MedKoo Cat#: 575076

Name: Ceftizoxime alapivoxil hydrochloride

CAS#: 135767-36-1

Chemical Formula: C22H29ClN6O8S2

Exact Mass: 604.1177

Molecular Weight: 605.08

Elemental Analysis: C, 43.67; H, 4.83; Cl, 5.86; N, 13.89; O, 21.15; S, 10.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AS-924 HCl; Ceftizoxime alapivoxil hydrochloride
IUPAC/Chemical Name
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-((2-amino-1-oxopropyl)amino)-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R-(6alpha,7beta(Z(S*))))-
InChi Key
AIRXGBDVYJWRGO-VBSBDVEKSA-N
InChi Code
InChI=1S/C22H28N6O8S2.ClH/c1-10(23)15(29)26-21-24-11(8-38-21)13(27-34-5)16(30)25-14-17(31)28-12(6-7-37-18(14)28)19(32)35-9-36-20(33)22(2,3)4;/h6,8,10,14,18H,7,9,23H2,1-5H3,(H,25,30)(H,24,26,29);1H/b27-13-;/t10-,14+,18+;/m0./s1
SMILES Code
Cl.CO\N=C(/C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)\c3csc(NC(=O)[C@H](C)N)n3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 605.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bhat AM, Soodan JS, Singh R, Dhobi IA, Hussain T, Dar MY, Mir M. Incidence of bovine clinical mastitis in Jammu region and antibiogram of isolated pathogens. Vet World. 2017 Aug;10(8):984-989. doi: 10.14202/vetworld.2017.984-989. Epub 2017 Aug 25. PubMed PMID: 28919694; PubMed Central PMCID: PMC5591490. 2: Liu S, Wang C, Fu YX. [Analysis of drug resistance of Acinetobacter baumannii in wound of children with traffic injury and its relationship with antibiotic use]. Zhonghua Shao Shang Za Zhi. 2017 Jul 20;33(7):404-409. doi: 10.3760/cma.j.issn.1009-2587.2017.07.002. Chinese. PubMed PMID: 28763905. 3: Hashizume H, Takahashi Y, Masuda T, Ohba SI, Ohishi T, Kawada M, Igarashi M. In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C. J Antibiot (Tokyo). 2017 Jul 26. doi: 10.1038/ja.2017.88. [Epub ahead of print] PubMed PMID: 28743973.