Synonym
Leucine thiorphan; Leu-thiorphan;
IUPAC/Chemical Name
(2-benzyl-3-mercaptopropanoyl)-L-leucine
InChi Key
PISCFNDSARITBO-KZUDCZAMSA-N
InChi Code
InChI=1S/C16H23NO3S/c1-11(2)8-14(16(19)20)17-15(18)13(10-21)9-12-6-4-3-5-7-12/h3-7,11,13-14,21H,8-10H2,1-2H3,(H,17,18)(H,19,20)/t13?,14-/m0/s1
SMILES Code
CC(C)C[C@@H](C(O)=O)NC(C(CS)CC1=CC=CC=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
309.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Dusser DJ, Nadel JA, Sekizawa K, Graf PD, Borson DB. Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea. J Pharmacol Exp Ther. 1988 Feb;244(2):531-6. PubMed PMID: 3279179.
7: Sekizawa K, Tamaoki J, Graf PD, Basbaum CB, Borson DB, Nadel JA. Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. J Pharmacol Exp Ther. 1987 Dec;243(3):1211-7. PubMed PMID: 2447268.
8: Sekizawa K, Tamaoki J, Nadel JA, Borson DB. Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea. J Appl Physiol (1985). 1987 Oct;63(4):1401-5. PubMed PMID: 2447055.
